Tumor thickness, depth of invasion, and Bcl-2 expression are correlated with FDG-uptake in oral squamous cell carcinomas
Tumor thickness, depth of invasion, and Bcl-2 expression are correlated with FDG-uptake in oral squamous cell carcinomas
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DOI：
10.1016/j.oraloncology.2009.03.009
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发表时间：
2009-10-01
期刊：
影响因子：
4.8
通讯作者：
Tatematsu, Masae
中科院分区：
文献类型：
--
作者：
Suzuki, Hidenori;Fukuyama, Ryuichi;Tatematsu, Masae
通过治疗前正电子发射断层扫描（PET）评估，口腔鳞状细胞癌（OSCC）的高[（18）F]-2-氟脱氧葡萄糖（FDG）摄取表明患者生存率低。在这项研究中，我们试图阐明在口腔鳞状细胞癌中高FDG摄取和低生存率之间密切相关的潜在病理学和生物学机制。对23名接受了术前FDG-PET和根治性手术的患者进行了评价。我们计算最大标准化摄取值（SUVmax）作为FDG摄取。定量测量肿瘤厚度和浸润深度。用葡萄糖转运蛋白-1、E-钙粘蛋白、β-连环蛋白、血管内皮生长因子（VEGF）、VEGF-C和Bcl-2的抗体对病理标本进行免疫组化染色，并对它们的表达进行光密度评估。SUVmax与肿瘤厚度和浸润深度均呈显著相关。与SUVmax < 12的患者相比，SUVmax >= 12的患者显示出显著更短的3年总生存期，与< 12. Tumors with SUVmax >SUVmax < 12的患者相比，SUVmax = 12的患者显示出显著更大的肿瘤厚度、浸润深度和平均Bcl-2强度。此外，肿瘤厚度>= 11.4 mm，浸润深度>= 11.8 mm，平均Bcl-2强度>= 50%与生存率低显著相关。结果提示SUVmax与口腔鳞癌的病理特征密切相关，是一个无创性的、预测患者预后的有用指标。(C)2009爱思唯尔有限公司保留所有权利。
High [(18)F]-2-fluorodeoxyglucose (FDG)-uptake of oral squamous cell carcinoma (OSCC), assessed by pretreatment positron emission tomography (PET), has indicated poor survival of patients. In this study, we sought to elucidate the underlying pathological and biological mechanisms of the close correlation in OSCC between high FDG-uptake and poor survival. Twenty-three patients who underwent both pretreatment FDG-PET and radical surgery were evaluated. We calculated the maximum standardized uptake value (SUVmax) as FDG-uptake. Tumor thickness and depth of invasion were quantitatively measured. Pathological specimens were immunohistochemically stained with antibodies to glucose transporter-1, E-cadherin, beta-catenin, vascular endothelial growth factor (VEGF), VEGF-C and Bcl-2, and their expressions were densitometrically assessed. SUVmax was significantly correlated with both tumor thickness and depth of invasion in simple regression analysis. Patients with SUVmax >= 12 exhibited significantly shorter 3-year overall survival than patients with SUVmax < 12. Tumors with SUVmax >= 12 showed significantly greater tumor thickness, depth of invasion and average Bcl-2 intensity than those with SUVmax < 12. Furthermore, tumor thickness >= 11.4 mm, depth of invasion >= 11.8 mm and average Bcl-2 intensity >= 50% were significantly correlated with poor survival. These results suggest that SUVmax in OSCC is significantly correlated with pathological features, and that it is both a non-invasive and useful parameter for predicting patients' prognosis. (C) 2009 Elsevier Ltd. All rights reserved.