INTERACTION WITH PUPS ENHANCES DOPAMINE RELEASE IN THE VENTRAL STRIATUM OF MATERNAL RATS - A MICRODIALYSIS STUDY
INTERACTION WITH PUPS ENHANCES DOPAMINE RELEASE IN THE VENTRAL STRIATUM OF MATERNAL RATS - A MICRODIALYSIS STUDY
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DOI：
10.1016/0091-3057(93)90523-v
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发表时间：
1993-07-01
影响因子：
3.6
通讯作者：
NYIREDI, S
中科院分区：
文献类型：
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作者：
HANSEN, S;BERGVALL, AH;NYIREDI, S
越来越多的证据表明，对多巴胺(DA)传递的干扰会扰乱老鼠的母性行为。因此，我们进行了脑微透析研究，以探讨婴儿是否能调节母鼠腹侧纹状体DA的释放。母鼠分离一夜后，腹侧纹状体细胞外DA、3，4-二羟基苯乙酸(DOPAC)、高香草酸(HVA)和5-羟基吲哚乙酸(5-HIAA)浓度显著升高。在这一阶段的实验中，护理是主要的行为。用花盆土污染幼鼠可引起更活跃的行为，并伴随着DA、DOPAC、HVA和5-HIAA的进一步增加。提示PUP对腹侧纹状体DA释放的刺激有利于亲代反应，如PUP的取回。
A growing body of evidence suggests that an interference with dopamine (DA) transmission disrupts maternal behavior in the rat. The present brain microdialysis study was therefore conducted to investigate whether infants can modulate ventral striatal DA release in mother rats. There was a significant rise in the extracellular concentrations DA, 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in the ventral striatum when mothers were reunited with their litters following separation overnight. Nursing was the predominant behavior during this phase of the experiment. More active behaviors were elicited by soiling pups with flowerpot earth, and this was accompanied by further increases in DA, DOPAC, HVA, and 5-HIAA. It is suggested that pup-induced stimulation of ventral striatal DA release facilitates parental responses such as pup retrieval.