Comparison of clinical and radiographic severity of juvenile-onset versus adult-onset ankylosing spondylitis
Comparison of clinical and radiographic severity of juvenile-onset versus adult-onset ankylosing spondylitis
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DOI：
10.1136/ard.2008.092304
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发表时间：
2009-09-01
影响因子：
27.4
通讯作者：
Inman, R. D.
中科院分区：
文献类型：
--
作者：
O'Shea, F. D.;Boyle, E.;Inman, R. D.
目的：在强直性脊柱炎(AS)的发病机制和临床病程中，一个尚未解决的重要问题是：幼年型强直性脊柱炎(JOAS)本身是一种临床实体，还是只是成年型AS的早期变异型(AOAS)。为了解决这一问题，进行了一项研究。方法：所有AS患者都来自一家大型脊柱炎诊所的数据库。症状起病年龄=17岁者。计算优势比(OR)，并根据病程和当前年龄进行调整。结果：267例AS患者中84例符合JOAS标准，183例符合AOAS标准。性别比(男性：JOAS 81%，AOAS 79%)和人类白细胞抗原B27状态(阳性：JOAS 75%，AOAS 81%)无差异。发病时的轴向/周围型不同，26%的JOAS表现为单一的周围型，而AOAS仅有4.6%(P
Objectives: An important unresolved issue in the pathogenesis and clinical course of ankylosing spondylitis (AS) is whether juvenile-onset AS (JoAS) is a clinical entity in its own right or just an earlier onset variant of adult-onset AS (AoAS). A study was undertaken to address this issue.Methods: All patients with AS were extracted from the database of a large spondylitis clinic. Those with symptom onset at = 17 years. Odds ratios (OR) were calculated and adjusted for disease duration and current age.Results: 267 patients with AS were identified; 84 met the criteria for JoAS and 183 met the criteria for AoAS. There were no differences in gender ratio (male: JoAS 81%, AoAS 79%) or in HLA-B27 status (positive: JoAS 75%, AoAS 81%). The axial/peripheral pattern of disease at presentation differed; an exclusively peripheral pattern was seen in 26% with JoAS but in only 4.6% of those with AoAS (p