Fecal Markers of Intestinal Inflammation and Permeability Associated with the Subsequent Acquisition of Linear Growth Deficits in Infants
Fecal Markers of Intestinal Inflammation and Permeability Associated with the Subsequent Acquisition of Linear Growth Deficits in Infants
复制标题
DOI：
10.4269/ajtmh.2012.12-0549
复制
发表时间：
2013-02-01
影响因子：
3.3
通讯作者：
Gottlieb, Michael
中科院分区：
文献类型：
--
作者：
Kosek, Margaret;Hague, Rashidul;Gottlieb, Michael
肠道感染与儿童线性生长衰竭有关。为了量化肠道炎症和线性生长衰竭之间的关系，在8个国家的无症状儿童粪便中进行了三种市购酶联免疫吸附试验（新蝶呤[NEO]、α -抗胰蛋白酶[AAT]和髓过氧化物酶[MPO]），并进行了纵向监测。来自537名儿童的样本贡献了1169个AAT， 916个MPO和954个NEO测试结果，这些结果与线性生长显著相关。当结合形成疾病活动度评分时，在控制腹泻病的发病率后，在测试后的6个月期间，得分最高的儿童比得分最低的儿童长了1.08厘米。这一套负担得起的非侵入性测试描述了那些有线性生长失败风险的人，并可用于改进干预措施的评估，以优化儿童早期关键时期的生长。
Enteric infections are associated with linear growth failure in children. To quantify the association between intestinal inflammation and linear growth failure three commercially available enzyme-linked immunosorbent assays (neopterin [NEO], alpha-anti-trypsin [AAT], and myeloperoxidase [MPO]) were performed in a structured sampling of asymptomatic stool from children under longitudinal surveillance for diarrhea] illness in eight countries. Samples from 537 children contributed 1,169 AAT, 916 MPO, and 954 NEO test results that were significantly associated with linear growth. When combined to form a disease activity score, children with the highest score grew 1.08 cm less than children with the lowest score over the 6-month period following the tests after controlling for the incidence of diarrheal disease. This set of affordable non-invasive tests delineates those at risk of linear growth failure and may be used for the improved assessments of interventions to optimize growth during a critical period of early childhood.