Hyper-branched poly(poly(ethylene glycol)methacrylate)-grafted surfaces by photo-polymerization with iniferter for bioactive interfaces.
Hyper-branched poly(poly(ethylene glycol)methacrylate)-grafted surfaces by photo-polymerization with iniferter for bioactive interfaces.
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DOI：
10.1016/j.actbio.2008.02.008
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发表时间：
2008-07
影响因子：
9.7
通讯作者：
Y. Joung;J. Choi;J. Bae;K. Park
中科院分区：
文献类型：
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作者：
Y. Joung;J. Choi;J. Bae;K. Park
以二硫代氨基甲酰基（DC）为引发剂，通过光聚合法制备了一种新型超支化表面，其结构包括聚乙二醇甲基丙烯酸酯（PEGMA）的茎链、枝链接枝和枝链接枝支链3种。对于这些表面，苯乙烯和先前合成的引发剂活化的链的自由基共聚被执行用于作为用于表面涂覆的基材。在直流电活化的表面，超支化聚（PEGMA）引入光聚合和二硫代氨基甲酰化。所有改性表面进行了分析，通过X射线光电子能谱（XPS）和水接触角测量。结果表明，以二硫代氨基甲酰基为引发剂，通过光聚合可以在聚氨酯表面构建高度超支化的聚（PEGMA）接枝结构，其中第一、第二和第三代分别形成了聚（PEGMA）的茎链、支链和枝链。我们的超支化表面可以通过光照射时间来调节，并且可以通过进料量或其他反应条件来控制。这种具有亲水性和链移动性的PEG链的高密度结构，接枝在表面上，预计将有效地用于生物可植入基底或微或纳米图案化表面，用于生物医学领域中生物活性分子的固定。
A new hyper-branched surface in which three species of architectures were constructed as stem chain, branched stem and twig chain-grafted branched chain of poly(poly(ethylene glycol)methacrylate) (poly(PEGMA)) by photo-polymerization using dithiocarbamyl group (DC) as iniferter was prepared and characterized. For these surfaces, radical copolymerization of styrene and an iniferter-activated chain that was previously synthesized was performed for using as base materials for surface coating. On a DC-activated surface, hyper-branched poly(PEGMA) was introduced by photo-polymerization and dithiocarbamylation. All modified surfaces were analyzed by X-ray photoelectron spectroscopy (XPS) and water contact angle measurements. Our results demonstrated that a highly hyper-branched graft architecture of poly(PEGMA) can be constructed on PU surface by photo-polymerization using dithiocarbamyl group as iniferter, in which first, second and third generation gave stem chain, branched chain and twig chain of poly(PEGMA), respectively. Our hyper-branched surfaces could be regulated by photo-irradiation time and might be controlled by feed amounts or other reaction conditions. This highly dense architecture of PEG chain with hydrophilicity and chain mobility, grafted on surface, is expected to be effectively utilized in bio-implantable substrates or micro- or nano-patterned surfaces for immobilization of bioactive molecules in biomedical fields.