Combined oral contraceptives and liver cancer

Combined oral contraceptives and liver cancer
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复方口服避孕药与肝癌

DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
S. Holck
S. Holck
中科院分区：
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文献类型：
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作者：
R. Molina;L. Martínez;O. Salas;A. Dabancens;T. Yun;C. Zhi‐heng;Huan Yong;A. Cuadros;N. Aristizabal;B. Modan;E. Ron;E. Alfandary;J. K. Mati;P. Kenya;A. Kungu;D. Gatei;P. Ibeziako;A. Abioye;T. Junaid;P. Aghadiuno;R. Apelo;Julietta R. De LaCruz;J. Baens;B. Canlas;S. Silpisornkosol;T. Pardthaisong;Boonlong Sivasomboom;C. Theetranont;B. Boosiri;S. Chutivongse;P. Virutamasen;C. Wongsrichanalai;Sermsri Sindhvananda;S. Koetsawang;D. Rachawat;O. Kiriwat;N. Chantarakul;P. Anthony;D. Thomas;J. Stanford;R. Ray;E. Noonan;S. Holck

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进行了一项多国、以医院为基础的病例对照研究，以评价类固醇避孕药与6种肿瘤的可能关系。根据122例新诊断的原发性肝癌病例和802例匹配对照的数据，曾使用复方口服避孕药的妇女患肝癌的相对危险度估计为0.71（95%CI 0.4-1.2）。未观察到风险随使用月数或首次或末次使用时间的一致趋势。单独的分析也显示使用复方口服避孕药与肝细胞癌（RR = 0.60）或胆管癌（RR = 1.22）之间没有关联。这项研究中的大多数妇女来自B型肝炎流行和肝癌发病率相对较高的地区，在大多数情况下，口服避孕药的使用时间很短。这些结果没有提供证据表明，在这种疾病的决定因素与进行本研究的国家相似的国家，短期使用口服避孕药会增加肝癌的风险。
A multi‐national, hospital‐based, case‐control study was conducted to evaluate the possible relationships of steroid contraceptives to 6 neoplasms. Based on data from 122 newly diagnosed cases of primary liver cancer and 802 matched controls, the relative risk of liver cancer in women who had ever used combined oral contraceptives was estimated to be 0.71 (95% Cl 0.4–1.2). No consistent trend in risk with months of use or time since first or last use was observed. Separate analyses also revealed no association between use of combined oral contraceptives and hepatocellular carcinoma (RR = 0.60) or cholangiocarcinoma (RR = 1.22). Most women in this study came from areas in which hepatitis B is endemic and rates of liver cancer are relatively high, and in most cases use of oral contraceptives was of short duration. These results provide no evidence that short‐term use of oral contraceptives enhances risk of liver cancer in countries where the determinants of this disease are similar to those observed in the countries where this study was conducted.