GENDER DIFFERENCES ON A BRIEF MEASURE OF COGNITIVE-FUNCTIONING IN ALZHEIMERS-DISEASE
GENDER DIFFERENCES ON A BRIEF MEASURE OF COGNITIVE-FUNCTIONING IN ALZHEIMERS-DISEASE
复制标题
DOI：
10.1001/archneur.1993.00540070069018
复制
发表时间：
1993-07-01
影响因子：
--
通讯作者：
HENDERSON, VW
中科院分区：
文献类型：
--
作者：
BUCKWALTER, JG;SOBEL, E;HENDERSON, VW
客观。-我们评估了一个简短的心理测量筛选工具的分数-简易精神状态检查（MMSE）-性别的可能影响，假设女性阿尔茨海默氏病（AD）的表现比男性更差。将通过事后项目分析探索显著的性别差异。案例研究设计。分层回归程序控制人口统计学变量（例如，年龄，痴呆症状持续时间，教育和痴呆家族史）对MMSE表现的可能影响，然后分析性别的影响。设置数据由南加州大学阿尔茨海默病研究中心的受试者经训练的神经心理学检查员收集。142名符合可能AD严格标准的受试者和121名非痴呆老年受试者被纳入研究。所有受试者均接受定期神经心理学测试。我们提取了MMSE分数和人口统计学数据来检验女性在MMSE上的表现比男性更差的假设。选择MMSE是因为它在临床和研究环境中广泛用于筛选痴呆的存在或严重程度。在控制了AD受试者的人口统计学变量后，我们观察到MMSE总分的预测方向存在显著差异，但非痴呆老年人样本的MMSE没有显著的性别影响。在AD患者中，性别相关差异仅限于MMSE项目的一个子集。结果表明，MMSE表现可能会有所不同，男性和女性之间的AD和差异可能只涉及离散领域的认知功能。尽管性别影响相对较小，但研究结果表明性别与AD研究的相关性。
Objective.-We evaluated scores on a brief psychometric screening instrument-the Mini-Mental State Examination (MMSE)-for possible effects of gender, hypothesizing that women with Alzheimer's disease (AD) would perform more poorly than men. A significant gender difference was to be explored with post hoc item analyses.Design.-Case-study design. A hierarchical regression procedure controlled for the possible influence on MMSE performance of demographic variables (eg, age, duration of dementia symptoms, education, and family history of dementia) before the effect of gender was analyzed.Setting-Data were gathered by trained neuropsychological examiners from subjects enrolled in the Alzheimer's Disease Research Center at the University of Southern California, Los Angeles.Subjects.-One hundred forty-two subjects who met strict criteria for probable AD and 121 nondemented elderly subjects were included in the study. All subjects underwent periodic neuropsychological testing. We extracted MMSE scores and demographic data to test the hypothesis that women would perform more poorly than men on the MMSE.Criterion Measure.-The MMSE was chosen because of its wide use in clinical and research settings to screen for the presence or severity of dementia.Results.-After controlling for the demographic variables for subjects with AD, we observed a significant difference in the predicted direction for total MMSE score, but there was no significant gender effect on the MMSE for the nondemented elderly sample. Among subjects with AD, gender-associated differences were limited to only a subset of MMSE items.Conclusions.-Results imply that MMSE performance may differ between men and women with AD and that differences might pertain only to discrete areas of cognitive functioning. Although gender effects were relatively small, findings indicate the relevance of gender to studies of AD.