Single-session effects of acute intermittent hypoxia on breathing function after human spinal cord injury.
Single-session effects of acute intermittent hypoxia on breathing function after human spinal cord injury.
复制标题
DOI：
10.1016/j.expneurol.2021.113735
复制
发表时间：
2021-08
影响因子：
5.3
通讯作者：
Fox EJ
中科院分区：
文献类型：
--
作者：
Sutor T;Cavka K;Vose AK;Welch JF;Davenport P;Fuller DD;Mitchell GS;Fox EJ
脊髓损伤（SCI）后，呼吸系统并发症是发病率和死亡率的主要原因。在啮齿类动物模型中，急性间歇性缺氧（AIH）触发脊髓呼吸运动可塑性，重复AIH可能具有恢复脊髓损伤患者呼吸能力的潜力。作为为这种影响提供原理证明的初步方法，我们测试了单期AIH对慢性脊髓损伤成人呼吸功能的影响。17名成人（13名男性；34.1±14.5岁；13名运动完全性脊髓损伤；受伤后6个月）完成了两个随机顺序的疗程，AIH与sham。AIH包括15.1分钟的发作（缺氧：10.3% O2，假手术：21% O2），穿插室内空气呼吸（1.5分钟，21%氧气）；没有试图调节动脉二氧化碳水平。测定0.1s内血氧饱和度（SpO2）、最大吸气和呼气压（MIP； MEP）、用力肺活量（FVC）、口腔咬合压（P0.1）。结果采用非参数Wilcoxon检验或2×2方差分析进行比较。基线SpO2为97.2±1.3%，假实验期间不变。在缺氧期间，SpO2下降到84.7±0.9%，并在正常缺氧期间恢复到基线水平。假手术后的结果与基线相比没有变化。与假手术相比，AIH后MIP明显增加(中位数分别为+10.8 cmH2O和- 2.6 cmH2O， 95%置信区间（- 18.7)- (- 4.3),p= 0.006）， Cohen效应值中等（0.68）。P0.1， MEP和FVC在aih后无变化。单次AIH会增加脊髓损伤成人的最大吸气压力产生，但不会增加其他呼吸功能。原因可能包括对吸气肌和呼气肌更大的空闲神经支配或aih诱导的吸气运动神经元池可塑性能力的差异。基于我们的发现，AIH对脊髓损伤患者呼吸能力的治疗潜力值得进一步研究。
After spinal cord injury (SCI) respiratory complications are a leading cause of morbidity and mortality. Acute intermittent hypoxia (AIH) triggers spinal respiratory motor plasticity in rodent models, and repetitive AIH may have the potential to restore breathing capacity in those with SCI. As an initial approach to provide proof of principle for such effects, we tested single-session AIH effects on breathing function in adults with chronic SCI. 17 adults (13 males; 34.1±14.5 years old; 13 motor complete SCI; >6 months post injury) completed two randomly ordered sessions, AIH versus sham. AIH consisted of 15, 1-minute episodes (hypoxia: 10.3% O2; sham: 21% O2) interspersed with room air breathing (1.5 minutes, 21% oxygen); no attempt was made to regulate arterial CO2 levels. Blood oxygen saturation (SpO2), maximal inspiratory and expiratory pressures (MIP; MEP), forced vital capacity (FVC), and mouth occlusion pressure within 0.1s (P0.1) were assessed. Outcomes were compared using nonparametric Wilcoxon’s tests, or a 2×2 ANOVA. Baseline SpO2 was 97.2 ± 1.3% and was unchanged during sham experiments. During hypoxic episodes, SpO2 decreased to 84.7 ± 0.9%, and returned to baseline levels during normoxic intervals. Outcomes were unchanged from baseline post-sham. Greater increases in MIP were evident post AIH vs. sham (median values; +10.8 cmH2O vs. −2.6 cmH2O respectively, 95% confidence interval (−18.7) – (−4.3), p=.006) with a moderate Cohen’s effect size (0.68). P0.1, MEP and FVC did not change post-AIH. A single AIH session increased maximal inspiratory pressure generation, but not other breathing functions in adults with SCI. Reasons may include greater spared innervation to inspiratory versus expiratory muscles or differences in the capacity for AIH-induced plasticity in inspiratory motor neuron pools. Based on our findings, the therapeutic potential of AIH on breathing capacity in people with SCI warrants further investigation.
登录
查看更多内容
影响因子：
13.6
作者：
Greenland S;Senn SJ;Rothman KJ;Carlin JB;Poole C;Goodman SN;Altman DG
通讯作者：
Altman DG
影响因子：
5.2
作者：
Dale-Nagle EA;Hoffman MS;MacFarlane PM;Satriotomo I;Lovett-Barr MR;Vinit S;Mitchell GS
通讯作者：
Mitchell GS
影响因子：
3.3
作者：
Hoffman, M. S.;Mitchell, G. S.
通讯作者：
Mitchell, G. S.
DOI：
10.1016/j.apmr.2016.07.001
发表时间：
2016-10-01
影响因子：
4.3
作者：
Krause, James S.;Cao, Yue;DiPiro, Nicole D.
通讯作者：
DiPiro, Nicole D.
影响因子：
1.7
作者：
Kirshblum, Steven C.;Waring, William;Krassioukov, Andrei
通讯作者：
Krassioukov, Andrei