A two-dimensional locally regularized strain estimation technique: preliminary clinical results for the assessment of benign and malignant breast lesions
A two-dimensional locally regularized strain estimation technique: preliminary clinical results for the assessment of benign and malignant breast lesions
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二维局部正则应变估计技术：评估乳腺良恶性病变的初步临床结果
DOI：
10.1117/12.877683
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Brusseau E
中科院分区：
文献类型：
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作者：
Brusseau E
我们之前开发了一种2D局部正则化应变估计技术，该技术已经用离体组织进行了验证。在这项研究中，我们的技术进行了评估与体内数据，通过检查乳腺异常的临床条件。方法的可靠性进行了分析，以及根据病变的良恶性性质的组织应变场。超声射频数据采集在两个中心的10个病变，五个被归类为纤维腺瘤，其他五个被归类为恶性肿瘤，主要是导管癌从I级到III级。我们开发的估计过程涉及最大限度地提高压缩前和压缩后图像之间的相似性标准（归一化相关系数或NCC），变形效应被认为是。如果该系数更接近1，则正确应变估计的概率更高。结果表明，我们的技术能够提供高质量的应变图像与临床数据。对于所有病变，获得压缩期间组织应变的电影，应变可达到15%。计算每个电影的NCC平均值，导致10种情况的平均值为0.93，最小值为0.87，最大值为0.98。这些高NCC值证实了应变估计的可靠性。此外，病变清楚地确定了10个案件的调查。最后，我们观察到与超声数据相比，应变图像可以揭示更重要的病变大小，并有助于评估病变的侵袭性。
We previously developed a 2D locally regularized strain estimation technique that was already validated with ex vivo tissues. In this study, our technique is assessed with in vivo data, by examining breast abnormalities in clinical conditions. Method reliability is analyzed as well as tissue strain fields according to the benign or malignant character of the lesion. Ultrasound RF data were acquired in two centers on ten lesions, five being classified as fibroadenomas, the other five being classified as malignant tumors, mainly ductal carcinomas from grades I to III. The estimation procedure we developed involves maximizing a similarity criterion (the normalized correlation coefficient or NCC) between pre- and post-compression images, the deformation effects being considered. The probability of correct strain estimation is higher if this coefficient is closer to 1. Results demonstrated the ability of our technique to provide good-quality strain images with clinical data. For all lesions, movies of tissue strain during compression were obtained, with strains that can reach 15%. The NCC averaged over each movie was computed, leading for the ten cases to a mean value of 0.93, a minimum value of 0.87 and a maximum value of 0.98. These high NCC values confirm the reliability of the strain estimation. Moreover, lesions were clearly identified for the ten cases investigated. Finally, we have observed with malignant lesions that compared to ultrasound data, strain images can put in relief a more important lesion size, and can help in evaluating the lesion invasive character.
徒手扫描过程中非诱导狗肿瘤病变的变形成像
DOI：
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发表时间：
2008
期刊：
IEEE International Symposium on Biomedical Imaging
影响因子：
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作者：
E. Brusseau;J. Deprez;F. Duboeuf;Fabienne Rigout;O. Basset
通讯作者：
O. Basset