THE VESTIBULAR NERVE OF THE CHINCHILLA .2. RELATION BETWEEN AFFERENT RESPONSE PROPERTIES AND PERIPHERAL INNERVATION PATTERNS IN THE SEMICIRCULAR CANALS
THE VESTIBULAR NERVE OF THE CHINCHILLA .2. RELATION BETWEEN AFFERENT RESPONSE PROPERTIES AND PERIPHERAL INNERVATION PATTERNS IN THE SEMICIRCULAR CANALS
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DOI：
10.1152/jn.1988.60.1.182
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发表时间：
1988-07-01
影响因子：
2.5
通讯作者：
GOLDBERG, JM
中科院分区：
文献类型：
--
作者：
BAIRD, RA;DESMADRYL, G;GOLDBERG, JM
1.应用轴突内标记技术研究半规管传入神经的反应特性与其周围神经支配模式之间的关系。向50个具有生理特征的单位注射辣根过氧化物酶（HRP）或荧光黄CH（LY），并将它们的突起追踪到嵴。大多数神经元的静息放电，放电规律性，以及对外部施加的电流和正弦头部旋转的反应进行了测定。终端领域进行了重建，并在前面的文件中，纤维被归类为花萼，bouton，或二型单位。2.为了确定轴突内样品是否具有代表性，将标记单元的生理特性与细胞外记录单元的样品的生理特性进行比较。还比较了轴突内单位的形态和那些标记的细胞外注射HRP到前庭神经的轴突内和两个细胞外样本之间的大多数差异可以解释为假设小直径的纤维在前一个样本中代表不足。3.标准化的变异系数（CV*），独立的放电率，被用来分类为定期，中间，或不规则的单位。CV* 范围为0.020 - 0.60。规则单位（CV* 小于或等于0.10）的数量超过不规则单位（CV* 大于或等于0.20）约3：1的比例，并有较高的静息放电。4.花萼单位总是不规则的。一个恢复布顿单位是定期的。的放电规律性的双形单位是有关他们的上皮位置，与那些发现在边缘的嵴有一个更经常的放电比那些位于更中心。二形单位，即使是那些具有非常相似的形态，可以在其放电规律不同。花萼和二形单位，它们在形态上不同，都可以是不规则的。这些观察结果表明，放电规律性不是由纤维的分支模式或其接触的毛细胞的数量和类型决定的。5.电流敏感性（β *）的传入，无论其外周神经支配模式，与CV* 强相关。这与放电规律性和电流敏感性是因果关系的概念是一致的，两者都是由传入神经末梢的峰后恢复机制决定的。（400字处删节）
1. The relation between the response properties of semicircular canal afferents and their peripheral innervation patterns was studied by the use of intra-axonal labeling techniques. Fifty physiologically characterized units were injected with horseradish peroxidase (HRP) or Lucifer yellow CH (LY) and their processes were traced to the crista. The resting discharge, discharge regularity, and responses to both externally applied galvanic currents and sinusoidal head rotations were determined for most neurons. Terminal fields were reconstructed and, as in the preceding paper, the fibers were classified as calyx, bouton, or dimorphic units. 2. To determine if the intra-axonal sample was representative, the physiological properties of the labeled units were compared with those of a sample of extracellularly recorded units. A comparison was also made between the morphology of the intra-axonal units and those labeled by extracellular injection of HRP into the vestibular nerve Most of the discrepancies between the intra-axonal and the two extracellular samples can be explained by assuming that small-diameter fibers are underrepresented in the former sample. 3. A normalized coefficient of variation (CV*), independent of discharge rate, was used to classify units as regular, intermediate, or irregular. The CV* ranged from 0.020 to 0.60. Regular units (CV* less than or equal to 0.10) outnumbered irregular units (CV* greater than or equal to 0.20) by an approximately 3:1 ratio and had higher resting discharges. 4. Calyx units were invariably irregular. The one recovered bouton unit was regular. The discharge regularity of dimorphic units was related to their epithelial location, with those found in the periphery of the crista having a more regular discharge than those located more centrally. Dimorphic units, even those with quite similar morphology, can differ in their discharge regularity. Calyx and dimorphic units, which differ in their morphology, can both be irregular. These observations imply that discharge regularity is not determined by the branching pattern of a fiber or the number and types of hair cells it contacts. 5. The galvanic sensitivity (beta*) of an afferent, irrespective of its peripheral innervation pattern, was strongly correlated with CV*. This is consistent with the notion that discharge regularity and galvanic sensitivity are causally related, both being determined by postspike recovery mechanisms of the afferent nerve terminal.(ABSTRACT TRUNCATED AT 400 WORDS)