New Insights into the Genetic Organization of the FK228 Biosynthetic Gene Cluster in Chromobacterium violaceum No. 968
New Insights into the Genetic Organization of the FK228 Biosynthetic Gene Cluster in Chromobacterium violaceum No. 968
复制标题
DOI：
10.1128/aem.01512-10
复制
发表时间：
2011-02-01
影响因子：
4.4
通讯作者：
Cheng, Yi-Qiang
中科院分区：
文献类型：
--
作者：
Potharla, Vishwakanth Y.;Wesener, Shane R.;Cheng, Yi-Qiang
FK228是FDA批准的抗癌天然产物，其生物合成基因簇先前已被鉴定和测序。该基因簇的遗传组织现已通过系统的基因缺失和转录分析来描绘。结果，基因簇被重新定义为包含12个基因：depA到depJ，depM和一个新鉴定的通路调控基因depR。
The biosynthetic gene cluster of FK228, an FDA-approved anticancer natural product, was identified and sequenced previously. The genetic organization of this gene cluster has now been delineated through systematic gene deletion and transcriptional analysis. As a result, the gene cluster is redefined to contain 12 genes: depA through depJ, depM, and a newly identified pathway regulatory gene, depR.