Salt-sensitive hypertension: contribution of chloride.
Salt-sensitive hypertension: contribution of chloride.
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DOI：
10.1126/science.6322303
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发表时间：
1984-03
期刊：
影响因子：
56.9
通讯作者：
S. Whitescarver;C. Ott;B. Jackson;G. Guthrie;T. Kotchen
中科院分区：
文献类型：
--
作者：
S. Whitescarver;C. Ott;B. Jackson;G. Guthrie;T. Kotchen
研究了负离子钠负荷对达尔盐敏感大鼠高血压发生的影响。给大鼠喂食含有正常或高浓度氯化钠或以碳酸氢钠、磷酸盐和氨基酸的混合物形式提供的高浓度钠的饲料5周。食用这些食物一周后，直到研究结束，接受高浓度氯化钠的大鼠的收缩压高于其他两组的大鼠。血浆容量、动脉pH、血浆Na+、K+、Cl-、Ca2+、肌酐浓度或肾髓性前列腺素E2生成方面，组间差异无统计学意义。与接受正常浓度氯化钠的动物相比，接受高浓度氯化钠或氨基酸的动物血浆肾素活性和血浆醛固酮浓度下降。因此，与钠一起摄入的阴离子改变了Dahl盐敏感大鼠高血压的发展和严重程度。
The effect of the anion associated with sodium loading on the development of hypertension in the Dahl salt-sensitive rat was determined. For 5 weeks rats were fed a diet containing normal or high concentrations of sodium chloride or high concentrations of sodium provided as a mixture of sodium bicarbonate, phosphate, and amino acids. After 1 week on these diets and until the end of the study the rats receiving high concentrations of sodium chloride had higher systolic blood pressures than the rats in the other two groups. There were no statistically significant group differences in plasma volume, arterial pH, or plasma concentrations of Na+, K+, Cl-, Ca2+, or creatinine, or in renomedullary prostaglandin E2 production. Compared to the animals receiving normal concentrations of sodium chloride, those receiving high concentrations of sodium chloride or amino acids showed decreased plasma renin activity and plasma aldosterone concentrations. Thus, the anion ingested with sodium alters the development and severity of hypertension in the Dahl salt-sensitive rat.