Radiotargeting agents for cancer therapy.
Radiotargeting agents for cancer therapy.
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DOI：
10.1517/17425247.2.6.981
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发表时间：
2005-11-01
影响因子：
6.6
通讯作者：
Kassis, Amin I
中科院分区：
文献类型：
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作者：
Kassis, Amin I
尽管外部射束治疗和放射性核素治疗的一般放射生物学原理是相同的，但在哺乳动物细胞中观察到的放射生物学效应存在显著差异。在外部射束治疗和近距离放射治疗中，发射由光子组成，而在放射性核素治疗中，感兴趣的辐射是颗粒。本文将探讨带电粒子穿越哺乳动物细胞所产生的生物效应的特殊性。此外，它还将强调当这些放射性核素和靶向放射性药物用于治疗癌症时所学到的东西。
Although the general radiobiological principles underlying external beam therapy and radionuclide therapy are the same, there are significant differences in the radiobiological effects observed in mammalian cells. In external beam therapy and brachytherapy, emissions are composed of photons, whereas in radionuclide therapy, the radiations of interest are particulate. This article will explore the special features that characterise the biological effects consequent to the traversal of charged particles through mammalian cells. In addition, it will highlight what has been learned when these radionuclides and targeting radiopharmaceuticals are used to treat cancers.