(±)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3
(±)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3
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DOI：
10.1021/ol403409v
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发表时间：
2014-01-17
期刊：
影响因子：
5.2
通讯作者：
Cheng, Yong-Xian
中科院分区：
文献类型：
--
作者：
Yan, Yong-Ming;Ai, Jun;Cheng, Yong-Xian
（±）-豆莞酰胺A（1）是一种具有新型四氢苯并[a]二苯并[b,e][1,4]二氧杂环己烯结构的不寻常的N - 乙酰多巴胺（NADA）三聚体，还有一对NADA二聚体对映异构体（2）从九香虫中分离得到。化合物1和2的结构通过光谱方法确定。发现化合物1是转化生长因子 - β1（TGF - β1）诱导的大鼠肾近端小管细胞中Smad3磷酸化的抑制剂，并在糖尿病条件下抑制系膜细胞中细胞外基质的表达。
(+/-)-Aspongamide A (1), an unusual trimer of N-acetyldopamine (NADA) bearing a novel tetrahydrobenzo[a]dibenzo[b,e][1,4]dioxine structure, and a pair of NADA dimeric enantiomers (2) were isolated from Aspongopus chinensis. The structures of compounds 1 and 2 were assigned using spectroscopic methods. Compound 1 was found to be an inhibitor of Smad3 phosphorylation in transforming growth factor-beta 1 (TGF-beta 1) induced rat renal proximal tubular cells and suppressed extracellular matrix expression in mesangial cells under diabetic conditions.