A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors
复制标题
DOI：
10.1002/j.1460-2075.1996.tb00629.x
复制
发表时间：
1996-06-03
期刊：
影响因子：
11.4
通讯作者：
Thompson, CB
中科院分区：
文献类型：
--
作者：
Duckett, CS;Nava, VE;Thompson, CB
昆虫杆状病毒凋亡抑制基因iap能阻止昆虫细胞的死亡。在这里，我们表明iap也可以防止哺乳动物细胞的细胞死亡。iap在不同物种中调节程序性细胞死亡的能力提高了iap细胞同源物存在的可能性。与这一假设相一致，我们已经分离出果蝇和人类基因编码IAP样蛋白（dILP和hILP）。与IAP一样，dILP和hILP都含有氨基末端杆状病毒IAP重复序列（BIR）和羧基末端RING指结构域。人ilp编码一种广泛表达的细胞质蛋白，可抑制转染细胞的凋亡。对表达序列标签数据库的分析表明，hilp是与iap相关的几个人类基因之一。总之，这些数据表明，iap和相关的细胞基因在细胞凋亡的调控中发挥着进化上保守的作用。
The baculovirus inhibitor of apoptosis gene, iap, can impede cell death in insect cells. Here we show that iap can also prevent cell death in mammalian cells. The ability of iap to regulate programmed cell death in widely divergent species raised the possibility that cellular homologs of iap might exist. Consistent with this hypothesis, we have isolated Drosophila and human genes which encode IAP-like proteins (dILP and hILP). Like IAP, both dILP and hILP contain amino-terminal baculovirus IAP repeats (BIRs) and carboxy-terminal RING finger domains. Human ilp encodes a widely expressed cytoplasmic protein that can suppress apoptosis in transfected cells. An analysis of the expressed sequence tag database suggests that hilp is one of several human genes related to iap. Together these data suggest that iap and related cellular genes play an evolutionarily conserved role in the regulation of apoptosis.