Isosulfan blue dye reactions during sentinel lymph node mapping for breast cancer
Isosulfan blue dye reactions during sentinel lymph node mapping for breast cancer
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DOI：
10.1097/00000539-200208000-00026
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发表时间：
2002-08-01
影响因子：
5.7
通讯作者：
Borgen, PI
中科院分区：
文献类型：
--
作者：
Montgomery, LL;Thorne, AC;Borgen, PI
在美国，前哨淋巴结（SLN）的鉴定需要使用tc -99m标记的胶体，1%异硫丹蓝染料，或两者同时使用，以追踪给定肿瘤的淋巴引流。我们报告了我们在乳腺癌SLN定位中异硫丹蓝染料的不良反应的经验。对乳腺癌SLN数据库进行了图表回顾；在1996年9月12日至2000年8月17日期间，在纪念斯隆-凯特琳癌症中心进行了使用异硫丹蓝染料的SLN活检的2392例连续患者。2392例患者中有39例（1.6%）在测图过程中有过敏反应记录。大多数反应（69%）产生荨麻疹、蓝色荨麻疹、全身性皮疹或瘙痒。低血压反应发生率为0.5%。虽然注射异硫丹蓝染料后的过敏反应是罕见的，这篇文章强调，当血液动力学不稳定发生在注射这种化合物后，需要怀疑过敏反应。我们的经验表明，支气管痉挛和呼吸衰竭是不寻常的，大多数患者不需要紧急插管，可以通过短期压力支持进行管理。此外，我们的数据表明，对磺胺过敏的患者对异硫丹蓝染料没有交叉敏感性。
In the United States, identification of the sentinel lymph node (SLN) requires the use of Tc-99m-labeled colloid, 1% isosulfan blue dye, or both to trace the lymphatic drainage of a given neoplasm. We report our experience with adverse reactions to isosulfan blue dye during SLN mapping in breast cancer. A chart review of the breast cancer SLN database was performed; it included 2392 sequential patients who underwent SLN biopsy involving isosulfan blue dye at Memorial Sloan-Kettering Cancer Center from September 12, 1996, to August 17,2000. Thirty-nine of 2392 patients (1.6%) had a documented allergic reaction during the mapping procedure. Most reactions (69%) produced urticaria, blue hives, a generalized rash, or pruritus. The incidence of hypotensive reactions was 0.5%. Although anaphylaxis after the injection of isosulfan blue dye is rare, this article highlights the need to suspect anaphylaxis when hemodynamic instability occurs after the injection of this compound. Our experience indicates that bronchospasm and respiratory compromise are unusual and that most patients do not require emergent intubation and can be managed with short-term pressor support. In addition, our data indicate that patients with a sulfa allergy do not display a cross-sensitivity to isosulfan blue dye.