Biodegradation of high-toughness double network hydrogels as potential materials for artificial cartilage
Biodegradation of high-toughness double network hydrogels as potential materials for artificial cartilage
复制标题
DOI：
10.1002/jbm.a.31043
复制
发表时间：
2007-05-01
影响因子：
4.9
通讯作者：
Osada, Yoshihito
中科院分区：
文献类型：
--
作者：
Azuma, Chinatsu;Yasuda, Kazunori;Osada, Yoshihito
本研究评价了四种新型高韧性双网络水凝胶作为人工软骨潜在材料的生物降解性。对于每种DN凝胶材料，共制备了12个试件，其中6个试件在不进行任何处理的情况下进行了力学性能测试。其余6个标本植入6只成年雌性兔的皮下组织内。在植入后6周，测量植入试件的力学性能和含水率。在聚(2-丙烯酰胺-2-甲基丙磺酸)/聚(N，N‘-二甲基丙烯酰胺)DN凝胶中，极限应力和切线模数分别从3.10和0.20 Mpa显著增加到5.40和0.37 Mpa，注入后含水率显著降低(94%~91%)。在聚2-丙烯酰胺-2-甲基丙磺酸和纤维素/二甲基丙烯酰胺共混凝胶中，注入后的应力(分别为11.4和1.90 Mpa)和弹性模量(分别为0.30和1.70 Mpa)和含水率变化不大(分别为90和85%)。细菌纤维素/明胶DN凝胶植入后，极限应力由4.30 Mpa降至1.98 Mpa，含水率显著增加(78%~86%)。本研究表明，除纤维素/明胶凝胶外，这些凝胶是一种具有潜在应用价值的人工软骨材料。(C)2006年威利期刊公司。
This study evaluated biodegradation properties of four novel high-toughness double network (DN) hydrogels as potential materials for artificial cartilage. Concerning each DN gel material, a total of 12 specimens were prepared, and 6 of the 12 specimens were examined to determine the mechanical properties without any treatments. The remaining 6 specimens were implanted into the subcutaneous tissue, using 6 mature female rabbits. At 6 weeks after implantation, the mechanical properties and the water content of the implanted specimens were measured. In the poly(2-acrylamide-2-methyl-propane sulfonic acid)/poly (N,N'-dimethyl acrylamide) DN gel, the ultimate stress and the tangent modulus were significantly increased from 3.10 and 0.20 MPa, respectively, to 5.40 and 0.37 MPa, respectively, with a significant reduction of the water content after implantation (94 to 91%). In the poly(2-acrylamide-2-methyl-propane sulfonic acid) /polyacrylamide DN gel and the cellulose /poly(dimethyl acrylamide) DN gel, the stress (11.4 and 1.90 MPa, respectively) and the modulus (0.30 and 1.70 MPa, respectively) or the water content rarely changed after implantation (90 and 85%, respectively). In the bacterial cellulose/gelatin DN gel, the ultimate stress was dramatically reduced from 4.30 to 1.98 MPa with a significant increase of the water content after implantation (78 to 86%). This study implied that these DN gels except for the cellulose/gelatin DN gel are potential materials that may meet the requirements of artificial cartilage. (c) 2006 Wiley Periodicals, Inc.