Genome sequence of an obligate intracellular pathogen of humans:: Chlamydia trachomatis
Genome sequence of an obligate intracellular pathogen of humans:: Chlamydia trachomatis
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DOI：
10.1126/science.282.5389.754
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发表时间：
1998-10-23
期刊：
影响因子：
56.9
通讯作者：
Davis, RW
中科院分区：
文献类型：
--
作者：
Stephens, RS;Kalman, S;Davis, RW
对1，042，519个碱基对的沙眼衣原体基因组的分析揭示了与衣原体复杂生物学相关的意想不到的特征。虽然衣原体缺乏许多生物合成能力，但它们保留了执行关键步骤和从哺乳动物宿主细胞获得的代谢物相互转化的功能。许多潜在的毒力相关的蛋白质也进行了表征。几个真核细胞染色质相关的结构域蛋白进行了鉴定，提出了一个真核细胞一样的机制衣原体类核凝聚和去凝聚。衣原体基因的系统发育嵌合体，包括大量来自真核生物的系统发育起源基因，意味着一个复杂的进化适应专性细胞内寄生。
Analysis of the 1,042,519-base pair Chlamydia trachomatis genome revealed unexpected features related to the complex biology of chlamydiae. Although chlamydiae lack many biosynthetic capabilities, they retain functions for performing key steps and interconversions of metabolites obtained from their mammalian host cells. Numerous potential virulence-associated proteins also were characterized. Several eukaryotic chromatin-associated domain proteins were identified, suggesting a eukaryotic-like mechanism for chlamydial nucleoid condensation and decondensation. The phylogenetic mosaic of chlamydial genes, including a Large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism.