THE EPIDEMIOLOGY OF INFLAMMATORY BOWEL-DISEASE - A LARGE, POPULATION-BASED STUDY IN SWEDEN
THE EPIDEMIOLOGY OF INFLAMMATORY BOWEL-DISEASE - A LARGE, POPULATION-BASED STUDY IN SWEDEN
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DOI：
10.1016/0016-5085(91)90202-v
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发表时间：
1991-02-01
期刊：
影响因子：
29.4
通讯作者：
ADAMI, HO
中科院分区：
文献类型：
--
作者：
EKBOM, A;HELMICK, C;ADAMI, HO
以往基于人群的炎症性肠病发病率研究受到数量少、持续时间短或病例发现不足的限制。为了解决这些问题，我们确定了1965年至1983年乌普萨拉卫生保健区所有确诊溃疡性结肠炎（n = 2509）或克罗恩病（n = 1469）的患者。溃疡性结肠炎男性患者和克罗恩病女性患者的年龄特异性发病率略高。溃疡性结肠炎和克罗恩病在城市的发病率高于农村地区。在研究期间，溃疡性结肠炎的年发病率从不到7 / 10万增加到12 / 10万以上，而克罗恩病的发病率仍然在5 / 10万至7 / 10万之间。溃疡性结肠炎发病率的增加是溃疡性直肠炎患者数量显著增加的结果。对5年出生队列的分析表明，1945年至1954年出生的人患溃疡性结肠炎和克罗恩病的风险更高，而这种影响是由今年上半年出生的人造成的。队列效应的季节性，加上疾病在城市的优势，表明环境因素可能与溃疡性结肠炎和克罗恩病有关。
Previous population-based incidence studies of inflammatory bowel disease are limited by small numbers, short duration, or inadequate case-finding. To address these problems, we identified all persons with confirmed ulcerative colitis (n = 2509) or Crohn's disease (n = 1469) in the Uppsala Health Care Region from 1965 to 1983. Age-specific incidence rates by sex were slightly greater for males with ulcerative colitis and females with Crohn's disease. Incidence rates for ulcerative colitis and Crohn's disease were higher in urban than rural areas. The annual incidence rate of ulcerative colitis increased from less than 7 per 100,000 to more than 12 per 100,000 during the study period, while the rate for Crohn's disease remained between 5 and 7 per 100,000. The increase in the incidence of ulcerative colitis was the result of a marked increase in the number of patients with ulcerative proctitis. Analyses by 5-year birth cohorts suggest that those born from 1945 through 1954 were at higher risk for ulcerative colitis and Crohn's disease, and that this effect was accounted for by those born in the first half of the year. The seasonality in the cohort effect, combined with the urban preponderance of disease, suggests that environmental causes may be involved in ulcerative colitis and Crohn's disease.