Role of lipids in urinary stones: Studies of calcium oxalate precipitation at phospholipid Langmuir monolayers
Role of lipids in urinary stones: Studies of calcium oxalate precipitation at phospholipid Langmuir monolayers
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DOI：
10.1021/la052503u
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发表时间：
2006-03-14
期刊：
影响因子：
3.9
通讯作者：
Khan, SR
中科院分区：
文献类型：
--
作者：
Talham, DR;Backov, R;Khan, SR
本文综述了作者在脂质单层上草酸钙生长的实验。草酸钙是大多数尿路结石的主要矿物质成分。在结石形成过程中，膜成分或主动或被动地与钙质矿物联系在一起，有人提出脂质组装起着重要作用，可能为初始成核事件提供了位点。朗缪尔单分子层允许系统地研究草酸钙在脂质组装中的非均相沉淀。探讨了脂质头基团的化学特性、单分子层的组织以及单分子层内异质性和相界的存在的影响。
This article reviews the authors' experiments on calcium oxalate growth at lipid monolayers. Calcium oxalate is the principal mineral component of most urinary Stones. Membrane constituents associate either actively or passively with calcitic minerals during stone formation, and it has been proposed that lipid assemblies play a significant role, possibly providing sites for the initial nucleation event. Langmuir monolayers allow systematic studies of the heterogeneous precipitation of calcium oxalate at lipid assemblies. The influences of the chemical identity of the lipid headgroup, the organization of the monolayer, and the presence of heterogeneities and phase boundaries within the monolayer have been explored.