Synaptic complex revisited; a homologous recombinase flips and switches bases.
Synaptic complex revisited; a homologous recombinase flips and switches bases.
复制标题
DOI：
10.1016/j.molcel.2004.09.010
复制
发表时间：
2004-09
期刊：
影响因子：
16
通讯作者：
O. Voloshin;R. Camerini‐Otero
中科院分区：
文献类型：
--
作者：
O. Voloshin;R. Camerini‐Otero
虽然目前还不清楚 RecA 及其真核同源物如何进行全基因组同源性搜索，但 Radding 及其同事在本期《分子细胞》（Folta-Stogniew et al., 2004）中报告说，同源识别或比对的后期阶段涉及 A:T 丰富区域的碱基翻转（局部熔化）和切换（退火）。
While it is still unclear how RecA and its eukaryotic homologs conduct genome-wide homology searches, Radding and colleagues report in this issue ofMolecular Cell(Folta-Stogniew et al., 2004) that the latter stages of homologous recognition or alignment involve base flipping (localized melting) and switching (annealing) at A:T rich regions.