Vimentin‐positive adenocarcinomas of the stomach: co‐expression of vimentin and cytokeratin
Vimentin‐positive adenocarcinomas of the stomach: co‐expression of vimentin and cytokeratin
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波形蛋白阳性胃腺癌：波形蛋白和细胞角蛋白的共表达
DOI：
10.1046/j.1365-2559.1996.d01-538.x
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发表时间：
1996
期刊：
影响因子：
6.4
通讯作者：
M. Tsuneyoshi
中科院分区：
文献类型：
--
作者：
T. Utsunomiya;T. Yao;K. Masuda;M. Tsuneyoshi
近年来，有报道波形蛋白在某些肿瘤中表达。本研究旨在阐明波形蛋白在胃实体型低分化腺癌中的表达及其意义。免疫组化，239低分化腺癌与固体成分的胃进行了染色波形蛋白。波形蛋白阳性病例也使用连续镜像切片通过CAM 5.2染色。我们发现15例（6.3%）波形蛋白阳性病例。其中12例显示出不同数量的横纹肌样细胞。8例弥漫性波形蛋白和细胞角蛋白同时表达。此外，4例共表达病例显示识别高分子量细胞角蛋白的角蛋白-903阳性染色。大多数共表达病例显示多边形肿瘤细胞弥漫性增殖，伴有局灶性细胞间接触。与89例波形蛋白阴性肿瘤相比，共表达病例的预后较差（P < 0.05）。
Recently, the expression of vimentin has been reported in some carcinomas. This study was designed to clarify the significance of vimentin expression in solid type poorly differentiated adenocarcinomas of the stomach. Immunohistochemically, 239 poorly differentiated adenocarcinomas with solid components of the stomach were stained for vimentin. Vimentin‐positive cases were also stained by CAM 5.2 using serial mirror sections. We found 15 (6.3%) vimentin‐positive cases. Twelve of them demonstrated varying amounts of rhabdoid‐like cells. Eight cases diffusely co‐expressed vimentin and cytokeratin simultaneously. In addition, four co‐expressing cases showed positive staining with Keratin‐903 which recognizes the high molecular‐weight cytokeratin. Most of the co‐expressing cases showed a diffuse proliferation of polygonal tumour cells with focal cell‐to‐cell contact. The prognosis of the co‐expressing cases was poor in comparison with that of the 89 vimentin‐negative tumours (P < 0.05).
影响因子：
56.9
作者：
BONIFAS, JM;ROTHMAN, AL;EPSTEIN, EH
通讯作者：
EPSTEIN, EH
在渗透性支持物上生长的人子宫宫颈上皮细胞——分化研究的新模型。
DOI：
10.1046/j.1432-0436.1994.56120107.x
发表时间：
1994
期刊：
Differentiation; research in biological diversity
影响因子：
--
作者：
Gorodeski,GI;Romero,MF;Hopfer,U;Rorke,E;Utian,WH;Eckert,RL
通讯作者：
Eckert,RL