CHARACTERIZATION OF OSTEOGENIC RESPONSE TO MECHANICAL STIMULATION IN CANCELLOUS BONE OF RAT CAUDAL VERTEBRAE
CHARACTERIZATION OF OSTEOGENIC RESPONSE TO MECHANICAL STIMULATION IN CANCELLOUS BONE OF RAT CAUDAL VERTEBRAE
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DOI：
10.1152/ajpendo.1993.265.2.e340
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发表时间：
1993-08-01
影响因子：
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通讯作者：
CHAMBERS, TJ
中科院分区：
文献类型：
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作者：
CHOW, JWM;JAGGER, CJ;CHAMBERS, TJ
我们最近开发了一种实验模型，在该模型中，将针插入13周龄大鼠的第7和第9尾椎，用于加载加压的第8尾椎。我们现在已经应用这个模型来评估大鼠松质骨对机械刺激的反应性。我们发现，每天暴露在与在相对温和的身体活动中观察到的骨骼相似的负荷下，30个周期/天，将松质表面板层骨形成率提高了140倍。骨形成率与骨骼加载的天数和负载的大小呈极显著相关（P < 0.0001）。300个周期的单次加载，即10分钟的加载时间，使骨形成增加到未加载对照组的24倍。骨吸收指标基本上与骨形成参数成反比。这些实验表明，大鼠松质骨对机械刺激非常敏感，表明机械环境是哺乳动物松质骨生理行为的主要决定因素。
We have recently developed an experimental model in which pins, inserted into the 7th and 9th caudal vertebrae of 13-wk-old rats, are used to load the 8th caudal vertebra in compression. We have now applied this model to assess the responsiveness of rat cancellous bone to mechanical stimulation. We found that daily exposure to loads that induce strains similar to those observed in bone during relatively gentle physical activity, for 30 cycles/day, increased the rate of lamellar bone formation on cancellous surfaces by up to 140-fold. Bone formation rate showed a highly significant (P < 0.0001) correlation with the number of days for which the bones were loaded and with the size of the load. A single loading episode of 300 cycles, representing a 10-min period of loading, increased bone formation to 24 times that in nonloaded controls. Indexes of bone resorption were essentially the inverse of the bone formation parameters. These experiments show that rat cancellous bone is exquisitely sensitive to mechanical stimulation and suggest that the mechanical environment is a major determinant of the physiological behavior of mammalian cancellous bone.