Association of Sex Hormones and Fat Distribution in Men with Different Obese and Metabolic Statuses.
Association of Sex Hormones and Fat Distribution in Men with Different Obese and Metabolic Statuses.
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DOI：
10.2147/ijgm.s351282
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发表时间：
2022
影响因子：
2.3
通讯作者：
Zhou HD
中科院分区：
文献类型：
--
作者：
Zhou YH;Guo Y;Wang F;Zhou CL;Tang CY;Tang HN;Yan DW;Zhou HD
虽然一些研究已经探索了性激素与葡萄糖代谢的关联，但性激素与体脂分布之间的关联（与胰岛素抵抗密切相关）尚未完全阐明。本研究旨在探讨不同肥胖和代谢状态的中国男性血清睾酮（T）和雌二醇（E2）水平与内脏脂肪组织（VAT）和皮下脂肪组织（SAT）质量的关系。收集中南大学湘雅二医院健康管理中心的128名男性，根据他们的肥胖和代谢综合征（MS）状态分为代谢健康的非超重/肥胖男性（MHNO）、代谢健康的超重/肥胖男性（MHO）和代谢不健康的超重/肥胖男性（MUO）。采用多元回归分析方法，估计性激素水平对体脂分布的影响以及体脂分布对性激素水平的影响。以脂肪质量参数为自变量，MHNO中SAT与T呈强负相关（β =-2.772，P = 0.034），MHO中VAT与E2呈正相关（β = 22.269，P = 0.009），MUO中SAT与T呈负相关（β =-3.315，P = 0.010）。以性激素为自变量，MHO中E2与VAT呈正相关（β =-176.259，P = 0.048），T与VAT呈负相关（β = 183.150，P = 0.029）。在MUO中，观察到T与SAT呈负相关（β =-213.689，P = 0.021）。E2与VAT相互影响，形成恶性循环，T与VAT呈负相关可能与MHO组MS发生率降低有关。不同肥胖和代谢状态的男性性激素与脂肪分布之间存在双向关系。中国临床试验注册中心，ChiCTR-EOC-16010194。已登记的逆行。
Although several studies have explored the association of sex hormones with glucose metabolism, the association between sex hormones and body fat distribution, which is closely related to insulin resistance, has not been fully elucidated. We have tried to explore the relationship of testosterone (T) and estradiol (E2) with visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) mass in Chinese men with different obese and metabolic statuses. A total of 128 men from the Health Management Center of the Second Xiangya Hospital, Central South University were collected and grouped in accordance with their obese and metabolic syndrome (MS) statuses: metabolically healthy non-overweight/obese men (MHNO), metabolically healthy overweight/obese men (MHO) and metabolically unhealthy overweight/obese men (MUO). Multiple regression analyses were performed to estimate contributions of sex hormones levels to the variations of body fat distribution and the contributions of body fat distribution to the variations of sex hormone levels. With fat mass parameters as independent variables, SAT had a strong negative association with T in MHNO (β = −2.772, P = 0.034), VAT was positively correlated with E2 in MHO (β = 22.269, P = 0.009), and SAT was negatively associated with T in MUO (β = −3.315, P = 0.010). With sex hormones as independent variables, E2 positively correlated with VAT (β = −176.259, P = 0.048), while T negatively correlated with VAT in MHO (β = 183.150, P = 0.029). In MUO, an inverse association of T with SAT was observed (β = −213.689, P = 0.021). E2 and VAT had a mutual influence, thus resulting in a vicious circle, and the negative correlation between T and VAT may be related to the decrease of the MS occurrence in the MHO group. There were bi-directional relationships between sex hormones and fat distribution in men with different obese and metabolic statuses. Chinese Clinical Trial Registry, ChiCTR-EOC-16010194. Retrospectively registered.