Comparison of genetic and endocrine control of renin and kallikrein in mouse submandibular gland.
Comparison of genetic and endocrine control of renin and kallikrein in mouse submandibular gland.
复制标题
小鼠颌下腺肾素和激肽释放酶的遗传和内分泌控制的比较。
DOI：
10.1016/0024-3205(82)90053-4
复制
发表时间：
1982
期刊：
影响因子：
6.1
通讯作者：
Ward,PE
中科院分区：
文献类型：
--
作者：
Wilson,CM;Reynolds,RC;Ward,PE
研究了品系、性别、垂体切除和激素处理对小鼠颌下腺肾素、激肽释放酶、S2266水解酶和BAEe酯酶活性的影响。肾素活性由小鼠1号染色体上的Rnr基因座决定。雌性SWR/J小鼠（Rnr s/Rnr s）的下颌下腺肾素活性比C57 BL/6 J小鼠（Rnr B/Rnr B）高1000倍。两种菌株具有相似的激肽释放酶活性。与同一品系的雌性小鼠相比，雄性小鼠中的肾素、BAEe酯酶和S2266水解酶显著更高，而激肽释放酶则不是。二氢睾酮和/或甲状腺素处理诱导雌性小鼠中的肾素、BAEe酯酶和S2266水解酶，对激肽释放酶几乎没有影响。所有四种酶的活性都被垂体切除术大大降低。二氢睾酮和甲状腺素都需要恢复肾素，BAEe酯酶，和S2266水解酶诱导的水平。双氢睾酮和。或者甲状腺素将激肽释放酶恢复到控制水平。我们的结论是，小鼠下颌下腺的肾素和激肽释放酶是在不同的遗传和内分泌控制。此外，合成底物S2266不是小鼠下颌下腺胞质溶胶中激肽释放酶活性的特异性底物。
The effects of strain, sex, hypophysectomy and hormone treatment on mouse submandibular gland renin, kallikrein, S2266 hydrolase, and BAEe esterase activities have been examined. Renin activity is determined by the Rnr locus on mouse Chromosome 1. Female SWR/J mice (Rnr s/Rnr s) have 1000-fold higher submandibular gland renin activity than C57BL/6J mice (Rnr b/Rnr b). Both strains have similar kallikrein activity. Renin, BAEe esterase, and S2266 hydrolase are substantially higher in male mice compared to females of the same strain whereas kallikrein is not. Dihydrotestosterone and/or thyroxine treatment induces renin, BAEe esterase, and S2266 hydrolase in female mice with little effect on kallikrein. All four enzyme activities are profoundly reduced by hypophysectomy. Dihydrotestosterone and thyroxine are both required to restore renin, BAEe esterase, and S2266 hydrolase to induced levels. Dihydrotestosterone and. or thyroxine restores kallikrein to control levels. We conclude that renin and kallikrein in the mouse submandibular gland are under different genetic and endocrine control. In addition, the synthetic substrate S2266 is not a specific substrate for kallikrein activity in mouse submandibular gland cytosol.