An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II
An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II
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DOI：
10.1126/science.1129818
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发表时间：
2006-09-15
期刊：
影响因子：
56.9
通讯作者：
Breukink, Eefjan
中科院分区：
文献类型：
--
作者：
Hasper, Hester E.;Kramer, Naomi E.;Breukink, Eefjan
羊毛硫抗生素是含有不寻常氨基酸的多环肽，其对细菌细胞具有结合特异性，靶向细菌细胞壁组分脂质II以形成孔并从而裂解细胞。然而，这些脂质II靶向羊毛硫抗生素的几个成员太短，不能跨越脂质双层，不能形成孔，但不知何故，它们保持其抗菌功效。我们描述了一种替代机制，lantibiotic家族的成员杀死革兰氏阳性菌，从细胞分裂部位（或隔膜）除去脂质II，从而阻止细胞壁的合成。
Lantibiotics are polycyclic peptides containing unusual amino acids, which have binding specificity for bacterial cells, targeting the bacterial cell wall component lipid II to form pores and thereby lyse the cells. Yet several members of these lipid II - targeted lantibiotics are too short to be able to span the lipid bilayer and cannot form pores, but somehow they maintain their antibacterial efficacy. We describe an alternative mechanism by which members of the lantibiotic family kill Gram-positive bacteria by removing lipid II from the cell division site ( or septum) and thus block cell wall synthesis.