The Mycobacterial Cell Envelope-Lipids
The Mycobacterial Cell Envelope-Lipids
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DOI：
10.1101/cshperspect.a021105
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发表时间：
2014-10-01
影响因子：
5.4
通讯作者：
Jackson, Mary
中科院分区：
文献类型：
--
作者：
Jackson, Mary
结核分枝杆菌（Mtb）脂质在结核病基础和转化研究的几乎每一个关键方面都留下了不可磨灭的印记。尽管对这些化合物的兴趣最初源于它们的丰度、结构多样性和抗原性，但它们对结核病发病机制的重要贡献以及从药物、疫苗、诊断和生物标志物开发的角度对它们的兴趣推动了该领域的持续研究。本文综述了脂质在结核分枝杆菌生理和致病性中的作用，以及近年来在鉴定靶向结核分枝杆菌生物发生的新先导化合物方面取得的令人兴奋的进展。
Mycobacterium tuberculosis (Mtb) lipids are indelibly imprinted in just about every key aspect of tuberculosis (TB) basic and translational research. Although the interest in these compounds originally stemmed from their abundance, structural diversity, and antigenicity, continued research in this field has been driven by their important contribution to TB pathogenesis and their interest from the perspective of drug, vaccine, diagnostic, and biomarker development. This article summarizes what is known of the roles of lipids in the physiology and pathogenicity of Mtb and the exciting developments that have occurred in recent years in identifying new lead compounds targeting their biogenesis.