Local regulation of ileal tone in healthy humans
Local regulation of ileal tone in healthy humans
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DOI：
10.1152/ajpgi.1997.272.1.g147
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发表时间：
1997-01-01
影响因子：
4.5
通讯作者：
Jian, R
中科院分区：
文献类型：
--
作者：
Coffin, B;Lemann, M;Jian, R
我们以前表明，一顿饭诱导，在人类回肠末端，延迟强直性松弛，这可能与回肠交付的膳食残留物和/或内源性分泌物的膳食释放。在这项研究中，我们评估了回肠内容物的某些成分对其运动活动的影响。在6名健康受试者中，我们研究了回肠张力和阶段性运动对不同等渗溶液（生理盐水、甘氨鹅去氧胆酸（GDCA）、甘油三酯和短链脂肪酸（SCFA））输注至回肠末端的反应。生理盐水没有改变紧张性活动，而GDCA和甘油三酯显著降低紧张性活动（袋内体积最大增加分别为139 +/- 7%和152 +/-16%，P < 0.01），SCFA显著增加紧张性活动（袋内体积最大减少72 +/-4%，P < 0.01）。两种溶液的相活性均无显著变化。我们的结论是：1）胆汁酸和甘油三酯不能在更近端的肠道中吸收，可能参与了进食后发生的回肠松弛; 2）化学感受器的局部刺激在回肠运动的调节中具有重要意义。
We previously showed that a meal induced, in the human terminal ileum, a delayed tonic relaxation, which could be related to the ileal delivery of meal residues and/or endogenous secretions released by a meal. In this study, we assessed the effects of some components of the ileal contents on its motor activity. In six healthy subjects, we studied ileal tonic and phasic motility in response to the infusion into the terminal ileum of different isotonic solutions: saline, glycochenodeoxycholic acid (GDCA), triglycerides, and short-chain fatty acids (SCFA). Tonic activity was not modified by saline, whereas it was significantly decreased by GDCA and triglycerides (maximal increase in intrabag volume 139 +/- 7% and 152 +/- 16%, respectively, P < 0.01), and significantly increased by SCFA (maximal decrease in intrabag volume 72 +/- 4%, P < 0.01). No significant change of phasic activity was evidenced with either solution. We conclude that I)bile acids and triglycerides not absorbed in the more proximal gut could be involved in the ileal relaxation occurring after eating and 2) local stimulation of chemoreceptors is of importance in the regulation of ileal motility.