The isometric length-tension diagram of isolated skeletal muscle fibers of the frog
The isometric length-tension diagram of isolated skeletal muscle fibers of the frog
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DOI：
10.1002/jcp.1030150103
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发表时间：
1940-02-01
影响因子：
--
通讯作者：
Street, SF
中科院分区：
文献类型：
--
作者：
Ramsey, RW;Street, SF
一根孤立的光纤连接的石英杆的放大偏转被拍照记录下来。每一长度的张力是从持续破伤风的最大值获得的。平均值(15磅。)最大张力[长划线]3534克/平方厘米。拉伸的未受刺激的单一肌肉纤维的平衡张力是由于肌膜，而肌肉物质本身的行为是可塑性或粘性的。静息张力小，不符合胡克-S定律。所产生的张力在静止长度(R.L.)处达到最大值；随着拉伸或缩短而减小(与拉伸近似线性，与缩短呈指数关系)；并且在从70%R.L.到200%R.L.的长度范围内完全可逆。如果允许纤维缩短到低于60%到70%R.L.(即，超过其R.L.的三分之一)，则纤维的性能和结构会发生显著的永久性变化。在刺激停止后，纤维仍然变短。分离的单个肌纤维可以缩短到20%R.L.如果测量长度-张力图下的总面积从200%R.L.到20%R.L.，大约等于XLO，其中TO=静息长度时的最大张力=LO。
The magnified deflections of a quartz lever to which an isolated fiber was attached were recorded photographically. The tension at each length was obtained from the maximum of a maintained tetanus. The mean (15 expts.) maximum tension[long dash]3534 g./cm2. The equilibrium tension of stretched unstimulated single muscle fibers is due to the sarcolemma, while the muscle substance itself behaves in a plastic or viscous fashion. The resting tension is small and does not obey Hooke''s law. The tension developed is a maximum at the resting length (R.L.); decreases with stretch or shortening (approximately linearly with stretch, exponentially with shortening); and is perfectly reversible over a range of lengths from 70% R.L. to 200% R.L. Striking permanent changes in the properties and structure of the fiber occur if it is allowed to shorten below 60 to 70% R.L. (i.e., more than one-third of its R.L.). The fiber remains shortened after cessation of the stimulus. Isolated single muscle fibers can shorten to 20% R.L. If the total area under the length-tension diagram from 200% R.L. to 20% R.L. is measured it is approximately equal to To X Lo where To = maximum tension at resting length = Lo.