Neighborhood characteristics and components of the insulin resistance syndrome in young adults - The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Neighborhood characteristics and components of the insulin resistance syndrome in young adults - The Coronary Artery Risk Development in Young Adults (CARDIA) Study
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DOI：
10.2337/diacare.25.11.1976
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发表时间：
2002-11-01
期刊：
影响因子：
16.2
通讯作者：
Kiefe, CI
中科院分区：
文献类型：
--
作者：
Roux, AVD;Jacobs, DR;Kiefe, CI
目的：研究年轻人胰岛素抵抗综合征（IRS）的六个组成部分与社区特征的关系。研究设计和方法：来自青年人冠状动脉风险发展（CARDIA）研究的横断面数据用于检查3093名年龄在28-40岁的非糖尿病成年人的社区特征与IRS的关系。测量BMI、空腹高密度脂蛋白胆固醇、甘油三酯、胰岛素、葡萄糖和收缩压合并成IRS评分。美国人口普查得出的社区特征被总结为社区社会经济得分，得分增加意味着社会经济优势增加。结果：在白人男性和女性中，IRS得分与社区社会经济得分呈负相关。在控制了个人收入和教育之后，邻里特征仍然与IRS得分相关（邻里得分第95百分位与第5百分位的调整后平均差异：男性为-0.24个标准差单位[SE = 0.12]，女性为-0.56个标准差单位[SE = 0.10]）。在黑人参与者中，社区评分与高收入和受教育程度人群的IRS评分呈负相关（男性平均差异为第95个百分位-0.54 [SE 0.26]，女性为-0.52 [SE 0.26]），但与低收入和受教育程度人群的IRS评分呈正相关或不相关（男性平均差异为0.60 [SE 0.21]，女性为0.00 [SE 0.16]）。结论：IRS评分早在成年早期就与社区特征相关。居住环境的特点可能与胰岛素抵抗的发展有关。
OBJECTIVE - To examine associations of neighborhood characteristics with six components of the insulin resistance syndrome (IRS) in young adults.RESEARCH DESIGN AND METHODS - Cross-sectional data from the Coronary Artery Risk Development in Young Adults (CARDIA) Study were used to examine associations of neighborhood characteristics with the IRS in 3,093 nondiabetic adults aged 28-40 years. Measures of BMI, fasting HDL cholesterol, triglycerides, insulin, glucose, and systolic blood pressure were combined into an IRS score. U.S. Census-derived neighborhood characteristics were summarized into a neighborhood socioeconomic score, with an increasing score signifying increasing socioeconomic advantage.RESULTS - Among white men and women, the IRS score was inversely related to neighborhood socioeconomic score. Neighborhood characteristics remained associated with the IRS score after controlling for personal income and education (adjusted mean differences for 95th vs. 5th percentile of neighborhood score: -0.24 standard deviation units [SE = 0.12] in men and -0.56 standard deviation units [SE = 0.10] in women). Among black participants, neighborhood score was inversely associated with IRS score in persons of high income and education (mean differences 95th vs. 5th percentile -0.54 [SE 0.26] in men and -0.52 [SE 0.26] in women) but positively associated or not associated with IRS score in persons of low income and education (mean differences 0.60 [SE 0.21] in men and 0.00 [SE 0.16] in women).CONCLUSIONS - The IRS score is associated with neighborhood characteristics as early as young adulthood. Features of residential environments may be related to the development of insulin resistance.