Antibody levels to recombinant tick calreticulin increase in humans after exposure to Ixodes scapularis (Say) and are correlated with tick engorgement indices.
Antibody levels to recombinant tick calreticulin increase in humans after exposure to Ixodes scapularis (Say) and are correlated with tick engorgement indices.
复制标题
人类接触肩胛硬蜱（Say）后，重组蜱钙网蛋白抗体水平会增加，并且与蜱充血指数相关。
DOI：
10.1093/oxfordjournals.aje.a009887
复制
发表时间：
1999
影响因子：
5
通讯作者：
Schwartz,BS
中科院分区：
文献类型：
--
作者：
Sanders,ML;Glass,GE;Nadelman,RB;Wormser,GP;Scott,AL;Raha,S;Ritchie,BC;Jaworski,DC;Schwartz,BS
The antibody responses of subjects who presented with a definiteIxodes scapularis(Say) tick bite were measured to determine the utility of the antibody response against recombinant tick calreticulin (rTC) as a biologic marker of tick exposure. Subjects bitten byl. scapularisevidenced an increase in anti-rTC antibody levels between visit 1 and visit 2 from 24.3 to 27.1 ng/μ serum (r= 88,p= 0.003), and levels remained elevated at visit 3 (p= 0.005). These anti-rTC antibody levels during visits 2 and 3 were significantly higher than those in four non-exposed controls. Tick engorgement indices, measured on the biting ticks, were found to be correlated with anti-rTC antibody levels (e.g., for visit 3: Pearson'sr= 0.357,p= 0.001). Tick engorgement index (TEI), ratio of body length to scutal width, was identified to be the only independent predictor of anti-rTC antibody levels in linear regression models. Logistic regression revealed that a bite from anl scapularistick that became engorged (TEI >3.4) was a risk factor for anti-rTC antibody seropositivity (adjusted odds ratio for age and bite location = 7.4 (95% confidence interval 2.1–26.4)). The anti-rTC antibody test had a sensitivity of 0.50 and a specificity of 0.86 for a bite froml. scapularisthat became engorged. Immunoblotting revealed that subjects made a specific anti-rTC antibody response. AmJ Epidemiol1999; 149: 777–84.
