The plasma membrane as an adaptable fluid mosaic
The plasma membrane as an adaptable fluid mosaic
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DOI：
10.1016/j.bbamem.2022.184114
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发表时间：
2023-01-05
影响因子：
3.4
通讯作者：
Shelby，Sarah A.
中科院分区：
文献类型：
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作者：
Veatch，Sarah L.;Rogers，Nat;Shelby，Sarah A.
Singer和Nicolson提出的流体镶嵌模型建立了一个强大的框架来询问经受住时间考验的生物膜。他们提出，膜是一种简单的流体，这意味着蛋白质和脂质随机分布的距离大于直接相互作用所决定的距离。在这里，我们提出了一个更新的模型，描述了一个空间适应性流体膜能够调整本地组成响应于膜平面外的力。这一修订是植根于热力学的脂质混合物，从最近的实验结果，并提出了新的膜功能模式。
The fluid mosaic model proposed by Singer and Nicolson established a powerful framework to interrogate biological membranes that has stood the test of time. They proposed that the membrane is a simple fluid, meaning that proteins and lipids are randomly distributed over distances larger than those dictated by direct interactions. Here we present an update to this model that describes a spatially adaptable fluid membrane capable of tuning local composition in response to forces originating outside the membrane plane. This revision is rooted in the thermodynamics of lipid mixtures, draws from recent experimental results, and suggests new modes of membrane function.