Temperature-resolved thermal analysis of cisplatin by evolved gas analysis-mass spectrometry
Temperature-resolved thermal analysis of cisplatin by evolved gas analysis-mass spectrometry
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DOI：
10.1016/j.jaap.2011.01.009
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发表时间：
2011-05
影响因子：
6
通讯作者：
Márta Juhász;Seiji Takahashi;T. Fujii
中科院分区：
文献类型：
--
作者：
Márta Juhász;Seiji Takahashi;T. Fujii
采用灵敏度高、实验步骤简单的演化气相分析-质谱法（EGA-MS）对顺铂在45-500℃下的非等温分解进行了研究。出乎意料的是，从235℃开始，总离子色谱出现了4个峰，对这些峰的质谱分析表明，顺铂在235 ~ 385℃时是热不稳定的，同时失去了nh3和HCl。首次在顺铂的电子冲击电离谱中检测到分子离子（M+），证实了顺铂以分子形式部分汽化。在较高的温度范围内，在m/z 370和335处发生了多种离子-分子反应，形成络合离子。
Evolved gas analysis-mass spectrometry (EGA-MS), which has high sensitivity and is a simple experimental procedure, was used to study the non-isothermal decomposition of cisplatin at 45–500°C. Unexpectedly, four peaks appeared in the total ion chromatogram starting at 235°C, and analysis of the mass spectra of the peaks indicated that cisplatin was thermally unstable and lost NH3and HCl simultaneously at 235–385°C. The molecular ion (M+) in the electron impact ionization spectrum of cisplatin was detected for the first time, which confirmed that cisplatin vaporized partially in molecular form. Various ion–molecule reactions occurred to form complex ions at m/z 370 and 335 at the higher part of the temperature range.