How the size distribution of magnetic nanoparticles determines their magnetic particle imaging performance
How the size distribution of magnetic nanoparticles determines their magnetic particle imaging performance
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DOI：
10.1063/1.3586776
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发表时间：
2011-05-02
影响因子：
4
通讯作者：
Trahms, L.
中科院分区：
文献类型：
--
作者：
Eberbeck, D.;Wiekhorst, F.;Trahms, L.
磁粒子成像（MPI）是一种强有力的生物医学成像技术，其空间和时间分辨率的关键取决于磁性纳米粒子（MNP）示踪剂的磁性。作者建立了各种MNP制剂的静态和动态磁化行为与其MPI性能的关系。虽然平均直径为6 nm的MNP仅达到三次谐波理论最大振幅的0.2%（在25 kA/m驱动场强下），但直径为19 nm的MNP达到57%。Resovist是一种临床批准的磁共振成像造影剂，其良好性能可通过MNP聚集体的存在来解释。(C)2011年美国物理学会。[doi：10.1063/1.3586776]
Spatial and temporal resolution of magnetic particle imaging (MPI), a powerful technique for biomedical imaging, depends crucially on the magnetic properties of the magnetic nanoparticle (MNP) tracer. The authors establish the relation of the static and the dynamic magnetization behavior of various MNP preparations to their MPI performance. While MNPs with a mean diameter of 6 nm achieve only 0.2% of the theoretical maximum amplitude of the third harmonic (at 25 kA/m drive field strength), those with 19 nm diameter attain 57%. The good performance of Resovist, a clinically approved contrast agent for magnetic resonance imaging, is explained by the presence of MNP aggregates. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3586776]