DECREASED SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHIC [(123)]I-BETA-CIT STRIATAL UPTAKE CORRELATES WITH SYMPTOM SEVERITY IN PARKINSONS-DISEASE
DECREASED SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHIC [(123)]I-BETA-CIT STRIATAL UPTAKE CORRELATES WITH SYMPTOM SEVERITY IN PARKINSONS-DISEASE
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DOI：
10.1002/ana.410380407
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发表时间：
1995-10-01
影响因子：
11.2
通讯作者：
INNIS, RB
中科院分区：
文献类型：
--
作者：
SEIBYL, JP;MAREK, KL;INNIS, RB
先前的研究已经利用单光子发射计算机断层扫描（SPECT）来证明特发性帕金森病（PD）患者的{I-123} β-CIT纹状体摄取减少。本研究扩展了这项工作，通过检查SPECT结果的措施，在一个更大的群体的PD患者不同的疾病严重程度。28名左旋多巴反应性PD患者（Hoehn-Yahr 1-4期）和27名健康对照者在注射{I-123} β-CIT后18至24小时进行SPECT扫描。特定于不可移位的纹状体摄取比率（指定为V-3“）与Hoehn-Yahr分期和统一帕金森病评定量表（Unified Parkinson's Disease Rating Scale，简称PDRS）分项评分相关。线性判别函数分析，利用纹状体摄取，壳核尾状核比率，同侧对侧不对称指数进行。纹状体示踪剂摄取（V-3“）减少与对侧和同侧纹状体的总TRIPS评分相关。与尾状核相比，壳核摄取相对减少，PD患者和对照组的平均壳核：尾状核比率分别为0.50 +/- 0.17和0.82 +/- 0.09。同侧：PD患者的对侧不对称性显著大于对照组。判别函数分析使用V-3“对同侧和对侧尾状核和壳核正确分类所有55例。这些数据表明，健康对照组和PD患者的{I-123} β-CIT SPECT测量值存在显著差异。SPECT测量与运动严重程度的显著相关性表明{I-123} β-CIT可能是PD疾病严重程度的有用标志物。
Previous studies have utilized single-photon emission computed tomography (SPECT) to demonstrate decreased {I-123}beta-CIT striatal uptake in idiopathic Parkinson disease (PD) patients. The present study extends this work by examining SPECT outcome measures in a larger group of PD patients with varying disease severity. Twenty-eight L-dopa-responsive PD patients (Hoehn-Yahr stages 1-4) and 27 healthy controls had SPECT scans at 18 to 24 hours after injection of {I-123}beta-CIT. Specific to nondisplaceable striatal uptake ratios (designated V-3 '') were correlated with Hoehn-Yahr stage and Unified Parkinson's Disease Rating Scale (UPDRS) subscores. Linear discriminant function analyses utilizing striatal uptakes, putamen-to-caudate ratios, and ipsilateral-contralateral asymmetry indices were performed. Decreased striatal tracer uptake (V-3 '') was correlated with total UPDRS score for both contralateral and ipsilateral striatum. Putamen uptake was relatively more reduced than caudate with mean putamen:caudate ratios of 0.50 +/- 0.17 and 0.82 +/- 0.09 for PD patients and controls, respectively. Ipsilateral: contralateral asymmetry was significantly greater in PD patients than controls. Discriminant function analysis utilizing V-3 '' for ipsilateral and contralateral caudate and putamen correctly classified all 55 cases. These data demonstrate marked differences in {I-123}beta-CIT SPECT measures in healthy controls and PD patients. The significant correlation of SPECT measures with motor severity suggests {I-123}beta-CIT may be a useful marker of disease severity in PD.