Regioselective C-H Amidation of (Alkyl)arenes by Iron(II) Catalysis
Regioselective C-H Amidation of (Alkyl)arenes by Iron(II) Catalysis
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DOI：
10.1021/acs.orglett.9b00697
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发表时间：
2019-04-19
期刊：
影响因子：
5.2
通讯作者：
Loh, Teck-Peng
中科院分区：
文献类型：
--
作者：
Ding, Yao;Zhang, Shen-Yuan;Loh, Teck-Peng
以磺酰叠氮化物为氮源，在铁(II)催化下进行了芳香族C-H键的非定向酰胺化反应。该反应具有较宽的底物范围和较好的区域选择性，表现在芳环与烷基链之间以及烷基芳烃的不同芳香位置上。该方法为以往报道中难以实现的芳香胺的合成提供了一种新的方法。
A nondirected amidation reaction of aromatic C-H bond was developed under iron(II) catalysis, using sulfonyl azides as the nitrogen source. The reaction displayed a broad substrate scope and good regioselectivities in the aspects of aromatic ring vs alkyl chain and different aromatic position of (alkyl)arenes. This method provided a new protocol for the synthesis of some aromatic amines, which were hard to achieve in a previous report.