Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation.
Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation.
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DOI：
10.1039/c7ob02039b
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发表时间：
2017-09
影响因子：
3.2
通讯作者：
James A. Rossi-Ashton;Richard J. K. Taylor;W. Unsworth
中科院分区：
文献类型：
--
作者：
James A. Rossi-Ashton;Richard J. K. Taylor;W. Unsworth
报道了三种不同的直接亚胺酰化（DIA）方法，其允许从亚胺和羧酸前体选择性地生成δ-内酰胺、β-内酰胺和四氢嘧啶酮（通过新颖的三组分偶联）。所有操作通过初始N-酰基异氰尿酸离子的形成和发散取决于反应条件和性质的基板。
Three divergent Direct Imine Acylation (DIA) procedures are reported that allow the selective generation of δ-lactams, β-lactams and tetrahydropyrimidinones (via a novel three-component coupling) from imine and carboxylic acid precursors. All operate via initial N-acyliminium ion formation and diverge depending on the reaction conditions and nature of the substrates.