SEROCONVERSION FOR HELICOBACTER-PYLORI
SEROCONVERSION FOR HELICOBACTER-PYLORI
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DOI：
10.1016/0140-6736(93)91473-y
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发表时间：
1993-08-07
期刊：
影响因子：
168.9
通讯作者：
MEUWISSEN, SGM
中科院分区：
文献类型：
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作者：
KUIPERS, EJ;PENA, AS;MEUWISSEN, SGM
幽门螺杆菌抗体的患病率随着年龄的增长而增加，但目前尚不清楚这是否是由于不同年龄组的感染率恒定，或者大多数感染发生在儿童时期。关于未经治疗的人群的感染率和感染过程的后续数据很少。我们测量了1979年至1983年在我们的内窥镜检查单位就诊的患者的幽门螺杆菌IgG抗体浓度。164例符合条件的患者中有115例（70%）参加了这项研究。幽门螺杆菌IgG抗体浓度测定两个血清样本，平均间隔11.5年。56名患者在首次访视时检测呈阳性。随访期间，2例患者发生感染（年感染率0.30%，95% CI 0.04-1.08%）。6名患者的感染证据消失：3名患者在胃手术后消失，其余3名患者的原因不明。在随访期间，不同年龄组的感染率无显著下降。抗体浓度不随年龄增加。这些结果有力地支持了儿童期显性感染率的概念。少数未接受根除治疗的患者可消除感染。
The prevalence of Helicobacter pylori antibodies increases with age, but it is unknown whether this is due to a constant rate of infection in different age groups, or whether most infection occurs in childhood. Follow-up data on infection rates and the course of infection in an untreated population are scarce. We measured H pylori IgG antibody concentrations in patients who were seen at our endoscopy unit between 1979 and 1983.115 of 164 eligible patients (70%) participated in the study. H pylori IgG antibody concentrations were measured in two serum samples taken with a mean interval of 11.5 years. 56 patients tested positive at the first visit. During follow-up, 2 patients became infected (annual infection rate 0.30%, 95% CI 0.04-1.08%). Evidence of infection disappeared in 6 patients: after gastric surgery in 3 and due to an unknown cause in the remaining 3 patients. A non-significant decrease of infection was shown in different age cohorts during follow-up. Antibody concentrations did not increase with age. These results strongly support the concept of dominant infection rates in childhood. Elimination of infection may occur in a few patients without eradication therapy.