NOVEL METHOD FOR IMAGE AVERAGING OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IMAGES
NOVEL METHOD FOR IMAGE AVERAGING OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IMAGES
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DOI：
10.1097/iae.0000000000002877
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发表时间：
2020-11-01
影响因子：
3.3
通讯作者：
Ledesma-Gil, Gerardo
中科院分区：
文献类型：
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作者：
Spaide, Richard F.;Ledesma-Gil, Gerardo
目的：建立一种光学相干断层扫描（OCT）血管成像平均化方法，以提高脉络膜毛细血管结构的显示。方法：将来自血管层的OCT血管造影数据的堆栈放置到传统数字彩色图像的红-绿-蓝通道中。浅血管丛置于蓝色通道，脉络膜毛细血管置于绿色通道，深血管丛置于红色通道。使用自动配准序列配准从9次单独OCT血管造影扫描中获得的红-绿-蓝图像，并对图像取平均值。然后将平均的红-绿-蓝图像分成三个平均的分量层。该技术是灵活的，任何血管层，如黄斑新生血管，也可以使用。结果：通过显示两种不同疾病的图像，证明了该成像方法的实用性。患者有家族性淀粉样变性、高血压、肾衰竭、肾移植和泼尼松使用史，随后发生中心性浆液性脉络膜视网膜病变，接受光动力疗法治疗。她有视网膜色素上皮色素沉着和广泛的自发荧光异常的改变。她表现出显着降低血管密度和血管形态的脉络膜毛细血管。一个患有弹性纤维性假黄瘤的病人，在早期的时候，视网膜下有玻璃小瘤样的沉积物，也显示出脉络膜毛细血管密度和血管形态的明显降低。将这些发现与年龄相似的健康对照组进行比较，没有异常。结论：详细的方法能够使用简单的自动方法平均脉络膜毛细血管OCT血管造影图像。图像平均提供了改善噪声OCT血管造影图像的机会，使得实际血管结构可见。
Purpose: To develop a method of averaging optical coherence tomography (OCT) angiography to improve visualization of choriocapillaris structure. Methods: A stack of OCT angiographic data from vascular layers were placed into the red-green-blue channels of a conventional digital color image. The superficial plexus was placed in the blue channel, choriocapillaris in the green, and deep vascular plexus in the red channel. The red-green-blue images derived from nine separate OCT angiographic scans were registered using an automatic registration sequence and the images were averaged. The averaged red-green-blue image was then split into the three averaged component layers. The technique is flexible and any vascular layer, such as macular neovascularization, can be used as well. Results: The utility of the imaging method was demonstrated by showing the imaging of two different diseases. A patient with a history of familial amyloidosis, hypertension, kidney failure, kidney transplantation, and prednisone use, followed by central serous chorioretinopathy treated by photodynamic therapy. She had alterations in retinal pigment epithelial pigmentation and widespread abnormalities of autofluorescence. She showed remarkably decreased vascular density and vessel configuration of her choriocapillaris. A patient with pseudoxanthoma elasticum with subretinal drusenoid deposits at an early age also showed marked decreased choriocapillaris density and vascular configuration. These findings were compared with healthy controls of similar age with no abnormalities. Conclusion: The detailed method is capable of averaging choriocapillaris OCT angiographic images using a simple automatic method. Image averaging offers opportunity to improve the noisy OCT angiographic images such that actual vascular structure is visible.