Quantification of cerebral tumour blood flow and permeability with T1-weighted dynamic contrast enhanced MRI: A feasibility study
Quantification of cerebral tumour blood flow and permeability with T1-weighted dynamic contrast enhanced MRI: A feasibility study
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DOI：
10.1016/j.neurad.2011.07.001
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发表时间：
2012-10-01
影响因子：
3.5
通讯作者：
Luypaert, Robert
中科院分区：
文献类型：
--
作者：
Dujardin, Martine I.;Sourbron, Steven P.;Luypaert, Robert
目的：最近，T1加权DCE-MRI被提出作为T2* 加权DSC-MRI的替代，用于定量脑肿瘤的灌注和渗透性。本可行性研究的目的是探讨该技术在不同肿瘤类型的临床潜力，使用基于病例的初步results.Patients和方法审查：数据分析的方法是适应脑灌注CT和应用在本研究中的一小组患者IV级胶质瘤和其他脑肿瘤。所提出的方法的可能用途也探讨了表征，后续行动和规划的治疗脑tumors.Results：参数地图明确区分肿瘤从周围的脑组织，并区分区域内的肿瘤呈现不同的特点，从而允许识别的重要目标区域活检和/或治疗。不同肿瘤的脑血流量（CBF）和较低的提取分数（E）的差异。在一年的过程中，从II级到IV级胶质瘤的进展的特点是CBF增加和E减少。结论：基于DCE-MRI的定量灌注和渗透性可能有助于肿瘤分级表征，活检指导，放疗计划，放疗监测和临床随访，从而提高脑肿瘤的非侵入性表征。(C)2011年Elsevier Masson SAS。All rights reserved.
Objectives: Recently, T1-weighted DCE-MRI was proposed as an alternative to T2*-weighted DSC-MRI for the quantification of perfusion and permeability in brain tumors. The aim of the present feasibility study was to explore the clinical potential of the technique in different tumor types using a case-based review of initial results.Patients and methods: The method for data analysis was adapted from cerebral perfusion CT and applied in this study to a small group of patients with grade IV glioma and other brain tumors. The possible use of the proposed methodology was also explored for characterizing, following-up and planning the therapy of brain tumors.Results: Parametric maps clearly differentiated tumor from the surrounding brain tissue, and also distinguished areas within the tumor presenting with different characteristics, thereby allowing identification of significant target areas for biopsy and/or treatment. Differences in cerebral blood flow (CBF) and lower extraction fractions (E) were observed in various tumors. Progression from a grade II to grade IV glioma over the course of a year was characterized by an increase in CBF and a decrease in E.Conclusion: DCE-MRI-based quantitative perfusion and permeability may be helpful for tumor-grade characterization, biopsy guidance, radiotherapy planning, radiotherapy monitoring and clinical follow-up, thereby improving the non-invasive characterization of brain tumors. (C) 2011 Elsevier Masson SAS. All rights reserved.