Right-sided cardiac function in healthy volunteers measured by first-pass radionuclide ventriculography and gated blood-pool SPECT:: Comparison with cine MRI
Right-sided cardiac function in healthy volunteers measured by first-pass radionuclide ventriculography and gated blood-pool SPECT:: Comparison with cine MRI
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DOI：
10.1111/j.1475-097x.2005.00635.x
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发表时间：
2005-11-01
影响因子：
1.8
通讯作者：
Petersen, CL
中科院分区：
文献类型：
--
作者：
Kjær, A;Lebech, AM;Petersen, CL
右心室（RV）功能是一系列心肺疾病的关注点。首过放射性核素心室造影（FP）、门控血池单光子发射断层扫描（GBPS）和心脏磁共振成像（MRI）是目前用于评价右心功能的三种无创方法。本研究的目的是比较这两种方法在测量右心功能时的一致性。平均年龄为44岁（范围：25-60岁），29%为女性。所有受试者均按照标准方案进行FP、GBPS和屏气电影MRI检查，MRI、FP和GBPS测量的RV射血分数（RVEF）的正常范围分别为0.49-0.72、0.44-0.66和0.40-0.69。Bland-Altman分析显示MRI和FP之间的平均差异（偏倚）为0.05（95% CI：0.03-0.08），MRI和GBPS之间的平均差异（偏倚）为0.06（95% CI：0.02-0.10）。FP和GBPS之间未发现系统偏倚。通过MRI和GBPS测量的RV舒张末期容积指数（RVEDVI）的正常值分别为37-95和29-91 ml m（-2）。RVEDVI之间的平均差异为6 ml m（-2）（95% CI：0-11）。(i)MRI、FP和GBPS之间RVEF的正常值不同，具有广泛的一致性范围，因此，如果采用不同方法测量，则难以评价随时间的变化，（ii）当采用MRI或GBPS测量时，RV体积在相同范围内，但具有广泛的一致性范围，（iii）如果MRI被视为金标准，则FP比GBPS更准确地测量RVEF。
Right ventricular (RV) function is of interest in an array of cardiopulmonary diseases. First-pass radionuclide ventriculography (FP), gated blood-pool single photon emission tomography (GBPS) and cardiac magnetic resonance imaging (MRI) are three currently used non-invasive methods for evaluation of right-sided cardiac function. The aim of our study was to compare the agreement between these methods when measuring right-sided cardiac function.Twenty-four healthy volunteers were included. Mean age was 44 years (range: 25-60) and 29% were females. All participants had FP, GBPS and breath-hold cine MRI performed according to standard protocols.Normal ranges for RV ejection fraction (RVEF) defined as mean +/- 2SD were 0.49-0.72, 0.44-0.66 and 0.40-0.69 when measured by MRI, FP and GBPS respectively. Bland-Altman analysis showed a mean difference (bias) between MRI and FP of 0.05 (95% CI: 0.03-0.08) and of 0.06 (95% CI: 0.02-0.10) between MRI and GBPS. No systematic bias was found between FP and GBPS. Normal values for RV end-diastolic volume index (RVEDVI) were 37-95 and 29-91 ml m(-2) when measured by MRI and GBPS respectively. The mean difference between RVEDVI was 6 ml m(-2) (95% CI: 0-11).(i) Normal values of RVEF differ between MRI, FP and GBPS with wide limits of agreement, accordingly it is difficult to evaluate changes over time if measured by different methods, (ii) RV volumes are in the same range when measured by MRI or GBPS but with wide limits of agreement, and (iii) if MRI is considered gold standard then FP is more accurate than GBPS for RVEF measurements.