Responses of primate LGN cells to moving stimuli involve a constant background modulation by feedback from area MT.
Responses of primate LGN cells to moving stimuli involve a constant background modulation by feedback from area MT.
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DOI：
10.1016/j.neuroscience.2013.04.055
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发表时间：
2013-08-29
期刊：
影响因子：
3.3
通讯作者：
Sillito AM
中科院分区：
文献类型：
--
作者：
Jones HE;Andolina IM;Grieve KL;Wang W;Salt TE;Cudeiro J;Sillito AM
我们研究了区域MT反馈对LGN细胞对视觉刺激反应的影响。我们使用局灶性GABA微离子导入可逆地阻断区域MT细胞的反应。失活区MT反馈在LGN细胞反应中产生了明确和可逆的变化。在大细胞、小细胞和小细胞LGN细胞类型中观察到了影响。从皮层中颞叶（MT）运动区到初级视觉皮层（V1）第6层的反馈连接具有将级联反馈影响从第6层皮质膝状体细胞驱动回外侧膝状体核（LGN）中继细胞的能力。这引入了折返运动信号影响视网膜输入通过LGN到视觉皮层的中继的可能性。问题是LGN细胞对运动刺激的反应是否涉及来自这种反馈的成分。通过产生可逆的局部药理学阻断MT方向柱的活性，我们显示了MT对猕猴LGN中的大细胞、小细胞和koniocellular细胞的反应的影响。LGN中的效应模式反映了MT位置失活的方向偏倚。这表明，运动刺激是通过视觉皮层区域和视觉丘脑形成的回路中的迭代相互作用捕获的。
We investigated the influence of area MT feedback on LGN cell responses to visual stimuli. We used focal GABA micro-iontophoresis to reversibly block area MT cell responses. Inactivating area MT feedback produced clear and reversible changes in LGN cell responses. Effects were observed across magno, parvo and koniocellular LGN cell types. The feedback connections from the cortical middle temporal (MT) motion area, to layer 6 of the primary visual cortex (V1), have the capacity to drive a cascaded feedback influence from the layer 6 cortico-geniculate cells back to the lateral geniculate nucleus (LGN) relay cells. This introduces the possibility of a re-entrant motion signal affecting the relay of the retinal input through the LGN to the visual cortex. The question is whether the response of LGN cells to moving stimuli involves a component derived from this feedback. By producing a reversible focal pharmacological block of the activity of an MT direction column we show the presence of such an influence from MT on the responses of magno, parvo and koniocellular cells in the macaque LGN. The pattern of effect in the LGN reflects the direction bias of the MT location inactivated. This suggests a moving stimulus is captured by iterative interactions in the circuit formed by visual cortical areas and visual thalamus.
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