Platelets Oxidative Stress in Indian Patients with Ischemic Heart Disease
Platelets Oxidative Stress in Indian Patients with Ischemic Heart Disease
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DOI：
10.1002/jcla.20363
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发表时间：
2010-01-01
影响因子：
2.7
通讯作者：
Bhattacharjee, Jayashree
中科院分区：
文献类型：
--
作者：
Garelnabi, Mahdi;Gupta, Vinod;Bhattacharjee, Jayashree
背景：氧化应激与动脉粥样硬化和血管组织损伤的发生有关。已知血小板活化和脂质过氧化在缺血性心脏病中起主要作用。本研究的目的是探讨印度缺血性心脏病患者血小板氧化应激的状态。方法：测定健康志愿者和心肌梗死、不稳定型和稳定型心绞痛患者各40例的血小板聚集、丙二醛（MDA）、血浆离子钙（2+）和抗氧化酶（谷胱甘肽过氧化物酶和超氧化物歧化酶）水平。结果：与对照组相比，两组患者血小板聚集、MDA和血浆离子Ca（2+）显著增加，这种增加伴随着抗氧化酶活性的总体下降；心肌梗死患者中谷胱甘肽过氧化物酶水平略有升高。结论：目前的研究结果表明，以MDA水平升高为标志的血小板脂质过氧化在缺血性心脏病中增强。这些患者的氧化应激增加伴随着血小板活化和抗氧化酶活性受损。j .中国。实验室。《肛门》，2010年24:49-54。(C) 2010 Wiley-Liss, Inc。
Background: Oxidative stress has been implicated in the development of atherosclerosis and vascular tissue injury. Both platelet activation and lipid peroxidation are known to play major role in ischemic heart disease. The purpose of this study was to investigate the status of platelets oxidative stress in Indian patients with ischemic heart disease. Methods: We measured platelets aggregation, malonyldialdehyde (MDA), plasma-ionized Ca(2+), and antioxidant enzymes, i.e., glutathione peroxidase and superoxide dismutase in healthy volunteers and patients with myocardial infarction, unstable and stable angina 40 subjects each. Results: Platelets aggregation, MDA, and plasma-ionized Ca(2+) have increased significantly across the patients groups compared with controls, this increase was accompanied by an overall decrease in the antioxidant enzymes activity; except for the slight increases in the glutathione peroxidase levels among the myocardial infarction patients. Conclusions: The current results suggest that platelet lipid peroxidation as marked by increased MDA level is augmented in ischemic heart diseases. The increased oxidative stress seen in these patients was accompanied by platelet activation and impaired antioxidant enzymes activity. J. Clin. Lab. Anal. 24:49-54, 2010. (C) 2010 Wiley-Liss, Inc.