Effects of dietary patterns on blood pressure - Subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial
Effects of dietary patterns on blood pressure - Subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial
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DOI：
10.1001/archinte.159.3.285
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发表时间：
1999-02-08
影响因子：
--
通讯作者：
Kennedy, BM
中科院分区：
文献类型：
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作者：
Svetkey, LP;Simons-Morton, D;Kennedy, BM
目的：探讨饮食模式对不同亚组人群血压的影响。方法：采用随机对照喂养研究方法，在4个学术医学中心进行。参与者是459名未经治疗的成年人，他们的收缩压低于160 mm Hg，舒张压在80至95 mm Hg之间。在为期3周的时间里，参与者被喂以“对照”饮食。然后他们被随机分为8周(1)对照饮食；(2)富含水果和蔬菜的饮食；或(3)富含水果、蔬菜和低脂乳制品，但饱和脂肪、总脂肪和胆固醇减少的组合饮食(DASH组合饮食)。体重和食盐摄入量保持不变。舒张压的变化是主要的结果变量，而收缩压是次要的结果。分析的亚组包括种族、性别、年龄、体重指数、受教育年限、收入、体力活动、饮酒和高血压状况。
Objective: To determine the effects of dietary patterns on blood pressure in subgroups.Methods: Dietary Approaches to Stop Hypertension (DASH) was a randomized controlled feeding study conducted at 4 academic medical centers. Participants were 459 adults with untreated systolic blood pressure less than 160 mm Hg and diastolic blood pressure 80 to 95 mm Hg. For 3 weeks, participants were fed a "control" diet. They were then randomized to 8 weeks of (1) control diet; (2) a diet rich in fruits and vegetables; or (3) a combination diet rich in fruits, vegetables, and low-fat dairy foods, and reduced in saturated fat, total fat, and cholesterol (the DASH combination diet). Weight and salt intake were held constant. Change in diastolic blood pressure was the primary outcome variable, and systolic blood pressure a secondary outcome. Subgroups analyzed included race, sex, age, body mass index, years of education, income, physical activity, alcohol intake, and hypertension status.Results: The combination diet significantly lowered systolic blood pressure in all subgroups (P