Free D-aspartate in mammals
Free D-aspartate in mammals
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DOI：
10.1248/bpb.28.1566
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发表时间：
2005-09-01
影响因子：
2
通讯作者：
Homma, H
中科院分区：
文献类型：
--
作者：
Furuchi, T;Homma, H
D-天冬氨酸（D-Asp）是哺乳动物神经和内分泌组织中存在的一种内源性氨基酸。在胚胎中观察到高浓度的D-Asp，其在分娩后在神经组织中消失，但在内分泌腺中暂时增加，特别是在特定阶段的垂体、松果体和肾上腺中。在松果体中，明显来自其他组织的D-Asp抑制实质细胞的褪黑激素分泌。此外，D-Asp水平在出生前和成熟期间在睾丸中增加。推测这种氨基酸是由脑下垂体和睾丸合成的。在睾丸中，生精小管内产生的D-Asp在释放后作用于Leydig细胞，通过激活类固醇生成急性调节蛋白的表达来增强睾酮合成。哺乳动物细胞似乎含有调节D-Asp稳态所需的所有分子组分，因为它们可以合成，释放，摄取和降解氨基酸。这些发现共同表明，D-Asp是哺乳动物体内的一种新型信使。
D-Aspartate (D-Asp) is an endogenous amino acid present in nervous and endocrine tissues in mammals. A high concentration Of D-Asp is observed in embryos, which disappears in nervous tissues after delivery, but increases temporarily in endocrine glands, particularly in the pituitary, pineal and adrenal glands at the specific stages. In the pineal gland, D-Asp that is apparently derived from other tissues suppresses melatonin secretion from parenchymal cells. Additionally, D-Asp levels increase in the testis just before birth and during maturation. The amino acid is presumed to be synthesized by the pituitary gland and testis. In the testis, D-Asp produced inside the seminiferous tubules acts on Leydig cells following release to enhance testosterone synthesis by activating the expression of Steroidogenic Acute Regulatory protein. Mammalian cells appear to contain all the molecular components required to regulate D-Asp homeostasis, as they can synthesize, release, take up, and degrade the amino acid. These findings collectively indicate that D-Asp is a novel type of messenger in the mammalian body.