THE ROLE OF THE RETICULO-ENDOTHELIAL CELL IN IRON METABOLISM
THE ROLE OF THE RETICULO-ENDOTHELIAL CELL IN IRON METABOLISM
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DOI：
10.1111/j.1365-2141.1960.tb06216.x
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发表时间：
1960-01-01
影响因子：
6.5
通讯作者：
FINCH, CA
中科院分区：
文献类型：
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作者：
NOYES, WD;BOTHWELL, TH;FINCH, CA
在7名年轻男性中，注射到循环中的非活性红细胞迅速消失。从7800到22300毫克。注射Hb，注射后15至30分钟内，血浆Hb含量为6至18%。注射的红细胞用放射性Fe标记，这表明Fe负荷的循环半衰期为0.15至0.95 mg。每公斤体重变化范围为33 - 150分钟，与给药量显著正相关。转铁蛋白结合的放射性铁被发现在血浆中的30分钟内。并达到18至22%。在2小时内注射的量。约一半的铁保留网状内皮细胞2周后，但在4名受试者流血的，以动员铁储备几乎没有留在那个时候。6周后，剩余的储存铁缓慢释放，但仍有大量残留在组织中。D.邓肯。
In 7 young men non-viable red cells injected into the circulation rapidly disappeared. Of from 7800 to 22, 300 mg. Hb injected, 6 to 18 per cent. was present as plasma Hb within 15 to 30 min. after injection. The injected red cells were labelled with radio-active Fe and this showed that the half-time of circulation of Fe loads of from 0.15 to 0.95 mg. per kg. bodyweight varied from 33 to 150 min. and was significantly and positively correlated with the amount given. Transferrin-bound radio-active Fe was found in plasma within 30 min. and reached 18 to 22 per cent. of the amount injected in 2 hr. About half the Fe was retained by reticuloendothelial cells after 2 weeks, but in 4 subjects bled in order to mobilize Fe reserves almost none remained at that time. The remaining stored Fe was slowly released but much remained in the tissues after 6 weeks. D. Duncan.