SCINTIMAMMOGRAPHY - THE COMPLEMENTARY ROLE OF TC-99M SESTAMIBI PRONE BREAST IMAGING FOR THE DIAGNOSIS OF BREAST-CARCINOMA
SCINTIMAMMOGRAPHY - THE COMPLEMENTARY ROLE OF TC-99M SESTAMIBI PRONE BREAST IMAGING FOR THE DIAGNOSIS OF BREAST-CARCINOMA
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DOI：
10.1148/radiology.196.2.7617855
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发表时间：
1995-08-01
期刊：
影响因子：
19.7
通讯作者：
KLEIN, SR
中科院分区：
文献类型：
--
作者：
KHALKHALI, I;CUTRONE, JA;KLEIN, SR
PURPOSE: To evaluate the complementary role of technetium-99m sestamibi scintimammography in improvement of the sensitivity and specificity of mammography in detection of carcinoma of the breast.MATERIALS AND METHODS: At 5 and 60 minutes after intravenous injection of Tc-99m sestamibi, scintimammograms were obtained in 147 women (age range, 18-73 years; mean age, 47.9 years +/- 10.2 [standard deviation]) with 153 lesions that warranted breast biopsy (102 lesions) or fine-needle aspiration cytologic analysis (51 lesions). There were 113 palpable and 40 nonpalpable lesions. Lesion size on mammograms was 0.8 x 0.6 cm to 15.0 x 11.0 cm (mean, 2.82 cm +/- 1.71 x 2.39 cm +/- 1.56).RESULTS: Scintimammographic findings were true-positive in 47 biopsy-confirmed carcinomas, true-negative in 91 benign lesions, false-positive in 11 lesions with benign histopathologic findings (fibrocystic disease [n = 8] or fibroadenoma [n = 3]), and false-negative in four lesions of infiltrating ductal carcinoma. The sensitivity of scintimammography was 92.2%; specificity, 89.2%; positive predictive value, 81.0%; and negative predictive value, 95.8%.CONCLUSION: The authors conclude that scintimammography is a sensitive test that can improve the detection of breast carcinoma.
