Spatiotemporal Self-Organization of Fluctuating Bacterial Colonies
Spatiotemporal Self-Organization of Fluctuating Bacterial Colonies
复制标题
DOI：
10.1103/physrevlett.119.188003
复制
发表时间：
2017-11-03
影响因子：
8.6
通讯作者：
Vanden-Eijnden, Eric
中科院分区：
文献类型：
--
作者：
Grafke, Tobias;Cates, Michael E.;Vanden-Eijnden, Eric
我们模拟了一个封闭的细菌系统，其运动诱导的相分离与缓慢的种群动态相耦合。在没有噪音的情况下，该系统既显示出静态的相分离，又显示了一个极限环，在此极限环中，全球人口的增加导致密集的细菌菌落形成，然后通过局部细胞死亡而下降，然后分散以重新启动循环。加上涨落，我们发现静态群体现在是亚稳定的，通过罕见的和强烈的非平衡路径在空间位置之间移动，而极限环变得几乎是周期性的，使得在每次再弥散事件之后，下一个群体在随机位置形成。这些结果暗示了生物膜-浮游生物生命周期的某些方面，可以通过结合大偏差理论的工具和全球种群密度起控制参数作用的分叉分析来解释。
We model an enclosed system of bacteria, whose motility-induced phase separation is coupled to slow population dynamics. Without noise, the system shows both static phase separation and a limit cycle, in which a rising global population causes a dense bacterial colony to form, which then declines by local cell death, before dispersing to reinitiate the cycle. Adding fluctuations, we find that static colonies are now metastable, moving between spatial locations via rare and strongly nonequilibrium pathways, whereas the limit cycle becomes almost periodic such that after each redispersion event the next colony forms in a random location. These results, which hint at some aspects of the biofilm-planktonic life cycle, can be explained by combining tools from large deviation theory with a bifurcation analysis in which the global population density plays the role of control parameter.