Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D1 and hypoxia-inducible factor-1α (HIF-1α)
Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D1 and hypoxia-inducible factor-1α (HIF-1α)
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DOI：
10.1038/sj.onc.1206995
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发表时间：
2003-12-04
期刊：
影响因子：
8
通讯作者：
Shvarts, A
中科院分区：
文献类型：
--
作者：
Bos, R;van Diest, PJ;Shvarts, A
B 细胞淋巴瘤基因 (BCL-6) 的上调通过细胞周期蛋白 D-1 的上调促进小鼠胚胎成纤维细胞和原代 B 细胞的永生化。由于cyclin D-1过度表达是不同癌症中的常见现象，因此BCL-6蛋白过度表达可能不仅限于淋巴瘤。在本研究中，通过免疫组织化学方法研究了 150 名乳腺癌患者的石蜡包埋标本和 10 份正常乳腺组织标本中 BCL-6 的表达。结果显示，BCL-6 在 24/150 (16%) 乳腺癌患者中过度表达（大于或等于 10% 的细胞），而在正常乳腺中低表达（
B-cell lymphoma gene (BCL-6) upregulation contributes to immortalization of mouse embryo fibroblast and primary B cells via upregulation of cyclin D-1. As cyclin D-1 overexpression is a common phenomenon in different cancers, BCL-6 protein overexpression may not be restricted to lymphomas. In this study, expression of BCL-6 was investigated by immunohistochemistry on paraffin-embedded specimens from 150 breast cancer patients and 10 specimens of normal breast tissue. The results showed BCL-6 overexpression (greater than or equal to10% of cells) in 24/150 (16%) breast cancer patients, whereas in normal breast low expression (