Iron transport machinery of human cells: players and their interactions.
Iron transport machinery of human cells: players and their interactions.
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DOI：
10.1016/b978-0-12-394390-3.00003-3
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发表时间：
2012
影响因子：
--
通讯作者：
Enns, Caroline A.
中科院分区：
文献类型：
--
作者：
Zhao, Ningning;Enns, Caroline A.
生物体和细胞一样，对铁保持着严格的控制。在人类和其他哺乳动物中，控制是通过调节体内铁的摄取而不是通过铁的排泄来实现的。本文综述了人类和小鼠调节铁摄取和铁在体内和细胞内分布的机制。特别强调在这一过程中涉及的铁转运蛋白。
Organisms, like cells, maintain tight control of iron. In humans as well as other mammals, control is achieved through the regulation of iron uptake into the body rather than through the excretion of iron. The mechanisms by which humans and mice regulate both iron uptake and the distribution of iron within the body and cells are reviewed. Special emphasis is given to the iron transporters involved in this process.